Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 711312..711911 Replicon chromosome
Accession NZ_CP029727
Organism Citrobacter sp. CRE-46 strain AR_0157

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag AN232_RS03580 Protein ID WP_110496330.1
Coordinates 711600..711911 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AN232_RS03575 Protein ID WP_038635893.1
Coordinates 711312..711599 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AN232_RS03560 708808..709710 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
AN232_RS03565 709707..710342 + 636 WP_038635897.1 formate dehydrogenase cytochrome b556 subunit -
AN232_RS03570 710339..711268 + 930 WP_006686145.1 formate dehydrogenase accessory protein FdhE -
AN232_RS03575 711312..711599 - 288 WP_038635893.1 helix-turn-helix domain-containing protein Antitoxin
AN232_RS03580 711600..711911 - 312 WP_110496330.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AN232_RS03585 712128..713036 + 909 WP_110496332.1 alpha/beta hydrolase -
AN232_RS03590 713101..713343 + 243 WP_069324888.1 type II toxin-antitoxin system ParD family antitoxin -
AN232_RS03595 713336..713623 + 288 WP_085049709.1 type II toxin-antitoxin system RelE/ParE family toxin -
AN232_RS03600 713629..714570 - 942 WP_032940213.1 fatty acid biosynthesis protein FabY -
AN232_RS03605 714615..715052 - 438 WP_003825289.1 D-tyrosyl-tRNA(Tyr) deacylase -
AN232_RS03610 715049..715921 - 873 WP_110496334.1 virulence factor BrkB family protein -
AN232_RS03615 715915..716514 - 600 WP_038635879.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12245.34 Da        Isoelectric Point: 9.8888

>T106547 WP_110496330.1 NZ_CP029727:c711911-711600 [Citrobacter sp. CRE-46]
MLFIETEIFTEDVKKLLDDDEYRRLQIFLAIQPDCGDLIQETGGLRKVRWRARGKGKRGGVRIIYFHQIRQSQIRLLLIY
QKGIKDDLTPQEKVLLRMLNEGW

Download         Length: 312 bp

>T106547 NZ_CP029727:c711911-711600 [Citrobacter sp. CRE-46]
ATGTTATTCATAGAAACGGAAATCTTCACTGAAGACGTCAAAAAATTACTGGATGATGATGAATACCGTAGATTACAGAT
ATTCCTTGCGATTCAGCCCGATTGCGGCGATCTGATACAAGAAACGGGGGGCCTGAGAAAGGTTCGCTGGAGAGCGCGAG
GGAAAGGAAAACGTGGCGGTGTGAGGATTATCTACTTTCATCAAATCAGACAATCACAAATTCGATTGTTGCTGATTTAT
CAGAAAGGGATCAAGGATGATCTGACTCCACAAGAAAAAGTACTGCTGCGGATGTTGAATGAGGGGTGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10761.36 Da        Isoelectric Point: 11.1842

>AT106547 WP_038635893.1 NZ_CP029727:c711599-711312 [Citrobacter sp. CRE-46]
MDKALFERLTQSMVQMNEIAEGTRQPSRTFHIDAMKIKEIRQSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR

Download         Length: 288 bp

>AT106547 NZ_CP029727:c711599-711312 [Citrobacter sp. CRE-46]
ATGGATAAGGCACTATTTGAGCGATTAACTCAAAGTATGGTTCAGATGAATGAGATTGCTGAAGGAACGCGGCAACCTTC
CCGCACCTTTCATATCGACGCCATGAAAATAAAGGAAATCCGCCAGTCATCGGGATTATCACAGACCCGTTTCGCAGATT
TGATATCGGTAAGTGTGGATACGTTGCGAAATTGGGAACAGGGGCGTCGTTCACCGACCGGTCCAGCAAAAGCGTTGTTA
CGCGCCATTGCCAACGATCCAAAACATGTCATTCAGGCGCTAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References