Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 711312..711911 | Replicon | chromosome |
Accession | NZ_CP029727 | ||
Organism | Citrobacter sp. CRE-46 strain AR_0157 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | AN232_RS03580 | Protein ID | WP_110496330.1 |
Coordinates | 711600..711911 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | AN232_RS03575 | Protein ID | WP_038635893.1 |
Coordinates | 711312..711599 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AN232_RS03560 | 708808..709710 | + | 903 | WP_003028691.1 | formate dehydrogenase O subunit beta | - |
AN232_RS03565 | 709707..710342 | + | 636 | WP_038635897.1 | formate dehydrogenase cytochrome b556 subunit | - |
AN232_RS03570 | 710339..711268 | + | 930 | WP_006686145.1 | formate dehydrogenase accessory protein FdhE | - |
AN232_RS03575 | 711312..711599 | - | 288 | WP_038635893.1 | helix-turn-helix domain-containing protein | Antitoxin |
AN232_RS03580 | 711600..711911 | - | 312 | WP_110496330.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
AN232_RS03585 | 712128..713036 | + | 909 | WP_110496332.1 | alpha/beta hydrolase | - |
AN232_RS03590 | 713101..713343 | + | 243 | WP_069324888.1 | type II toxin-antitoxin system ParD family antitoxin | - |
AN232_RS03595 | 713336..713623 | + | 288 | WP_085049709.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
AN232_RS03600 | 713629..714570 | - | 942 | WP_032940213.1 | fatty acid biosynthesis protein FabY | - |
AN232_RS03605 | 714615..715052 | - | 438 | WP_003825289.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
AN232_RS03610 | 715049..715921 | - | 873 | WP_110496334.1 | virulence factor BrkB family protein | - |
AN232_RS03615 | 715915..716514 | - | 600 | WP_038635879.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12245.34 Da Isoelectric Point: 9.8888
>T106547 WP_110496330.1 NZ_CP029727:c711911-711600 [Citrobacter sp. CRE-46]
MLFIETEIFTEDVKKLLDDDEYRRLQIFLAIQPDCGDLIQETGGLRKVRWRARGKGKRGGVRIIYFHQIRQSQIRLLLIY
QKGIKDDLTPQEKVLLRMLNEGW
MLFIETEIFTEDVKKLLDDDEYRRLQIFLAIQPDCGDLIQETGGLRKVRWRARGKGKRGGVRIIYFHQIRQSQIRLLLIY
QKGIKDDLTPQEKVLLRMLNEGW
Download Length: 312 bp
>T106547 NZ_CP029727:c711911-711600 [Citrobacter sp. CRE-46]
ATGTTATTCATAGAAACGGAAATCTTCACTGAAGACGTCAAAAAATTACTGGATGATGATGAATACCGTAGATTACAGAT
ATTCCTTGCGATTCAGCCCGATTGCGGCGATCTGATACAAGAAACGGGGGGCCTGAGAAAGGTTCGCTGGAGAGCGCGAG
GGAAAGGAAAACGTGGCGGTGTGAGGATTATCTACTTTCATCAAATCAGACAATCACAAATTCGATTGTTGCTGATTTAT
CAGAAAGGGATCAAGGATGATCTGACTCCACAAGAAAAAGTACTGCTGCGGATGTTGAATGAGGGGTGGTAA
ATGTTATTCATAGAAACGGAAATCTTCACTGAAGACGTCAAAAAATTACTGGATGATGATGAATACCGTAGATTACAGAT
ATTCCTTGCGATTCAGCCCGATTGCGGCGATCTGATACAAGAAACGGGGGGCCTGAGAAAGGTTCGCTGGAGAGCGCGAG
GGAAAGGAAAACGTGGCGGTGTGAGGATTATCTACTTTCATCAAATCAGACAATCACAAATTCGATTGTTGCTGATTTAT
CAGAAAGGGATCAAGGATGATCTGACTCCACAAGAAAAAGTACTGCTGCGGATGTTGAATGAGGGGTGGTAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10761.36 Da Isoelectric Point: 11.1842
>AT106547 WP_038635893.1 NZ_CP029727:c711599-711312 [Citrobacter sp. CRE-46]
MDKALFERLTQSMVQMNEIAEGTRQPSRTFHIDAMKIKEIRQSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR
MDKALFERLTQSMVQMNEIAEGTRQPSRTFHIDAMKIKEIRQSSGLSQTRFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPKHVIQALR
Download Length: 288 bp
>AT106547 NZ_CP029727:c711599-711312 [Citrobacter sp. CRE-46]
ATGGATAAGGCACTATTTGAGCGATTAACTCAAAGTATGGTTCAGATGAATGAGATTGCTGAAGGAACGCGGCAACCTTC
CCGCACCTTTCATATCGACGCCATGAAAATAAAGGAAATCCGCCAGTCATCGGGATTATCACAGACCCGTTTCGCAGATT
TGATATCGGTAAGTGTGGATACGTTGCGAAATTGGGAACAGGGGCGTCGTTCACCGACCGGTCCAGCAAAAGCGTTGTTA
CGCGCCATTGCCAACGATCCAAAACATGTCATTCAGGCGCTAAGATAA
ATGGATAAGGCACTATTTGAGCGATTAACTCAAAGTATGGTTCAGATGAATGAGATTGCTGAAGGAACGCGGCAACCTTC
CCGCACCTTTCATATCGACGCCATGAAAATAAAGGAAATCCGCCAGTCATCGGGATTATCACAGACCCGTTTCGCAGATT
TGATATCGGTAAGTGTGGATACGTTGCGAAATTGGGAACAGGGGCGTCGTTCACCGACCGGTCCAGCAAAAGCGTTGTTA
CGCGCCATTGCCAACGATCCAAAACATGTCATTCAGGCGCTAAGATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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