Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3046166..3046818 Replicon chromosome
Accession NZ_CP029715
Organism Serratia marcescens strain AR_0131

Toxin (Protein)


Gene name higB Uniprot ID A0A7D6BTF4
Locus tag AM378_RS14570 Protein ID WP_033635775.1
Coordinates 3046166..3046510 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A086GAN0
Locus tag AM378_RS14575 Protein ID WP_004931828.1
Coordinates 3046516..3046818 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM378_RS14555 3042508..3044766 - 2259 WP_048321906.1 molybdopterin guanine dinucleotide-containing S/N-oxide reductase -
AM378_RS14565 3044987..3046006 + 1020 WP_033649496.1 HTH-type transcriptional regulator GalR -
AM378_RS14570 3046166..3046510 + 345 WP_033635775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM378_RS14575 3046516..3046818 + 303 WP_004931828.1 helix-turn-helix transcriptional regulator Antitoxin
AM378_RS14580 3046846..3048108 - 1263 WP_033649495.1 diaminopimelate decarboxylase -
AM378_RS14585 3048242..3049165 + 924 WP_033649494.1 LysR family transcriptional regulator -
AM378_RS14590 3049193..3050101 - 909 WP_015378928.1 LysR family transcriptional regulator -
AM378_RS14595 3050210..3051094 + 885 WP_048321907.1 MBL fold metallo-hydrolase -
AM378_RS14600 3051163..3051810 + 648 WP_033649493.1 DsbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-85)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13409.48 Da        Isoelectric Point: 10.6087

>T106494 WP_033635775.1 NZ_CP029715:3046166-3046510 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLTRPHADTLYFSDAVRQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T106494 NZ_CP029715:3046166-3046510 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTGCAGACGTTCGGCCCGCAGTTGACGCGGCCGCATGCCGATACGCTGTATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCGTTCAACATCGCGGGCGCCCTTTCAGGGTGTTTTTCGCCTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGTGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11080.97 Da        Isoelectric Point: 10.1998

>AT106494 WP_004931828.1 NZ_CP029715:3046516-3046818 [Serratia marcescens]
MAKPLSQLIDKLDPAVVAAARQKADQEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT106494 NZ_CP029715:3046516-3046818 [Serratia marcescens]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGACCAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATAAAGCTGTCGTCGCTCAAACGCTATATCGAGGCCATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAACACCGCCGCATGACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6BTF4

Antitoxin

Source ID Structure
AlphaFold DB A0A086GAN0

References