Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2589587..2590089 Replicon chromosome
Accession NZ_CP029692
Organism Escherichia coli strain SD134209

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag DL800_RS15905 Protein ID WP_000767829.1
Coordinates 2589587..2589841 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag DL800_RS15910 Protein ID WP_001259255.1
Coordinates 2589838..2590089 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DL800_RS15875 2584602..2584829 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
DL800_RS15880 2584843..2585901 - 1059 WP_000492340.1 transport protein YeeE -
DL800_RS15885 2586080..2587438 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
DL800_RS15890 2587428..2587490 - 63 WP_010723108.1 membrane protein YoeI -
DL800_RS15895 2587705..2588634 - 930 WP_000803331.1 LysR family transcriptional regulator -
DL800_RS15900 2588680..2589504 - 825 WP_000754755.1 SDR family oxidoreductase -
DL800_RS15905 2589587..2589841 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
DL800_RS15910 2589838..2590089 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
DL800_RS15915 2590373..2590423 + 51 WP_001364200.1 his operon leader peptide -
DL800_RS15925 2590569..2591468 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
DL800_RS15930 2591474..2592778 + 1305 WP_001345258.1 histidinol dehydrogenase -
DL800_RS15935 2592775..2593854 + 1080 WP_000102292.1 histidinol-phosphate transaminase -
DL800_RS15940 2593851..2594918 + 1068 WP_000080054.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T106453 WP_000767829.1 NZ_CP029692:c2589841-2589587 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T106453 NZ_CP029692:c2589841-2589587 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT106453 WP_001259255.1 NZ_CP029692:c2590089-2589838 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT106453 NZ_CP029692:c2590089-2589838 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References