106396

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 727896..728589 Replicon chromosome
Accession NZ_CP029687
Organism Escherichia coli strain E706

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag DMI84_RS03920 Protein ID WP_000415584.1
Coordinates 727896..728192 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag DMI84_RS03925 Protein ID WP_000650107.1
Coordinates 728194..728589 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DMI84_RS03880 722984..723298 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
DMI84_RS03885 723329..723910 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
DMI84_RS03895 724229..724561 + 333 WP_000917684.1 DUF2645 family protein -
DMI84_RS03900 724607..725956 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
DMI84_RS03905 725953..726612 - 660 WP_001221493.1 two-component system response regulator QseB -
DMI84_RS03910 726764..727156 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
DMI84_RS03915 727209..727691 + 483 WP_000183505.1 transcriptional regulator -
DMI84_RS03920 727896..728192 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
DMI84_RS03925 728194..728589 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
DMI84_RS03935 728722..730329 + 1608 WP_063120833.1 ABC transporter substrate-binding protein -
DMI84_RS03940 730467..732725 + 2259 WP_072671900.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T106396 WP_000415584.1 NZ_CP029687:727896-728192 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T106396 NZ_CP029687:727896-728192 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT106396 WP_000650107.1 NZ_CP029687:728194-728589 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT106396 NZ_CP029687:728194-728589 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References