Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2622669..2622853 Replicon chromosome
Accession NZ_CP029685
Organism Staphylococcus aureus strain CMRSA-3

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag C7M54_RS13960 Protein ID WP_000482650.1
Coordinates 2622746..2622853 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2622669..2622729 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7M54_RS13935 2618199..2618366 - 168 WP_001790576.1 hypothetical protein -
C7M54_RS13945 2618597..2620330 - 1734 WP_112366879.1 ABC transporter ATP-binding protein/permease -
C7M54_RS13950 2620355..2622118 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2622669..2622729 + 61 - - Antitoxin
C7M54_RS13960 2622746..2622853 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
C7M54_RS13965 2622987..2623373 - 387 WP_000779358.1 flippase GtxA -
C7M54_RS13970 2623641..2624783 + 1143 WP_001176863.1 glycerate kinase -
C7M54_RS13975 2624843..2625502 + 660 WP_000831298.1 membrane protein -
C7M54_RS13980 2625684..2626895 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
C7M54_RS13985 2627018..2627491 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T106390 WP_000482650.1 NZ_CP029685:c2622853-2622746 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T106390 NZ_CP029685:c2622853-2622746 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT106390 NZ_CP029685:2622669-2622729 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References