Detailed information of TA system TA106379

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2156273..2156572
• Replicon: chromosome
• Accession: NZ_CP029685
• Organism: Staphylococcus aureus strain CMRSA-3

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: C7M54_RS11345
• Protein ID: WP_011447039.1
• Coordinates: 2156396..2156572 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2156273..2156328 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7M54_RS11300	2151607..2151867	+	261	WP_001791826.1	hypothetical protein	-
C7M54_RS11305	2151920..2152270	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
C7M54_RS11310	2152952..2153401	+	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
C7M54_RS11315	2153496..2153831	-	336	Protein_2088	SH3 domain-containing protein	-
C7M54_RS11325	2154481..2154972	-	492	WP_031774374.1	staphylokinase	-
C7M54_RS11330	2155163..2155918	-	756	WP_000861038.1	CHAP domain-containing protein	-
C7M54_RS11335	2155930..2156184	-	255	WP_016023528.1	phage holin	-
C7M54_RS11340	2156236..2156343	+	108	WP_001791821.1	hypothetical protein	-
-	2156265..2156404	+	140	NuclAT_0	-	-
-	2156265..2156404	+	140	NuclAT_0	-	-
-	2156265..2156404	+	140	NuclAT_0	-	-
-	2156265..2156404	+	140	NuclAT_0	-	-
-	2156273..2156328	+	56	-	-	Antitoxin
C7M54_RS11345	2156396..2156572	-	177	WP_011447039.1	putative holin-like toxin	Toxin
C7M54_RS11350	2156722..2157018	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
C7M54_RS11355	2157076..2157363	-	288	WP_001040261.1	hypothetical protein	-
C7M54_RS11360	2157410..2157562	-	153	WP_001153681.1	hypothetical protein	-
C7M54_RS11365	2157552..2161337	-	3786	WP_000582158.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2151920..2208980	57060

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T106379 WP_011447039.1 NZ_CP029685:c2156572-2156396 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106379 NZ_CP029685:c2156572-2156396 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT106379 NZ_CP029685:2156273-2156328 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin