Detailed information of TA system TA106376

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1996449..1996631
• Replicon: chromosome
• Accession: NZ_CP029685
• Organism: Staphylococcus aureus strain CMRSA-3

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: C7M54_RS10275
• Protein ID: WP_001801861.1
• Coordinates: 1996449..1996544 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1996572..1996631 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C7M54_RS10225	1992109..1992735	+	627	WP_000669046.1	hypothetical protein	-
C7M54_RS10230	1992776..1993120	+	345	WP_000627551.1	DUF3969 family protein	-
C7M54_RS10235	1993218..1993769	+	552	WP_000414205.1	hypothetical protein	-
C7M54_RS10240	1993987..1994628	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
C7M54_RS10245	1994742..1994927	-	186	WP_000809857.1	hypothetical protein	-
C7M54_RS10250	1994929..1995105	-	177	WP_000375476.1	hypothetical protein	-
C7M54_RS10255	1995116..1995499	-	384	WP_000070811.1	hypothetical protein	-
C7M54_RS10265	1996103..1996246	-	144	WP_001549059.1	transposase	-
C7M54_RS10275	1996449..1996544	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1996572..1996631	-	60	-	-	Antitoxin
C7M54_RS10280	1996667..1996768	+	102	WP_001791893.1	hypothetical protein	-
C7M54_RS10285	1996746..1996922	-	177	Protein_1936	transposase	-
C7M54_RS10290	1997116..1997493	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1970411..2047712	77301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T106376 WP_001801861.1 NZ_CP029685:1996449-1996544 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T106376 NZ_CP029685:1996449-1996544 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT106376 NZ_CP029685:c1996631-1996572 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin