Detailed information of TA system TA106370

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4488103..4488705
• Replicon: chromosome
• Accession: NZ_CP029682
• Organism: Salmonella sp. FORC89

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: FORC89_RS21805
• Protein ID: WP_001159635.1
• Coordinates: 4488394..4488705 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FORC89_RS21800
• Protein ID: WP_000362050.1
• Coordinates: 4488103..4488393 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC89_RS21785 (4485596)	4485596..4486498	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
FORC89_RS21790 (4486495)	4486495..4487130	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
FORC89_RS21795 (4487127)	4487127..4488056	+	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
FORC89_RS21800 (4488103)	4488103..4488393	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
FORC89_RS21805 (4488394)	4488394..4488705	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
FORC89_RS21810 (4488923)	4488923..4489852	+	930	WP_001127705.1	alpha/beta hydrolase	-
FORC89_RS21815 (4489938)	4489938..4490249	+	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
FORC89_RS21820 (4490246)	4490246..4490692	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
FORC89_RS21825 (4490707)	4490707..4491648	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
FORC89_RS21830 (4491693)	4491693..4492130	-	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
FORC89_RS21835 (4492127)	4492127..4492999	-	873	WP_000921423.1	virulence factor BrkB family protein	-
FORC89_RS21840 (4492993)	4492993..4493592	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T106370 WP_001159635.1 NZ_CP029682:c4488705-4488394 [Salmonella sp. FORC89]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T106370 NZ_CP029682:c4488705-4488394 [Salmonella sp. FORC89]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT106370 WP_000362050.1 NZ_CP029682:c4488393-4488103 [Salmonella sp. FORC89]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT106370 NZ_CP029682:c4488393-4488103 [Salmonella sp. FORC89]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97