Detailed information of TA system TA106352

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2443572..2443797
• Replicon: chromosome
• Accession: NZ_CP029682
• Organism: Salmonella sp. FORC89

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: FORC89_RS11895
• Protein ID: WP_000813254.1
• Coordinates: 2443572..2443727 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2443739..2443797 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC89_RS11860	2438679..2438960	-	282	WP_000445513.1	phage holin family protein	-
FORC89_RS11865	2438950..2439138	-	189	WP_001688615.1	putative holin	-
FORC89_RS11870	2439132..2439455	-	324	Protein_2324	tellurite/colicin resistance protein	-
FORC89_RS11875	2441626..2442162	-	537	WP_000640113.1	DUF1133 family protein	-
FORC89_RS11880	2442159..2442449	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
FORC89_RS11885	2442449..2443048	-	600	WP_000940751.1	DUF1367 family protein	-
FORC89_RS11890	2443111..2443281	-	171	WP_000734094.1	hypothetical protein	-
FORC89_RS11895	2443572..2443727	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2443739..2443797	+	59	-	-	Antitoxin
FORC89_RS11900	2444154..2445086	+	933	WP_000556390.1	hypothetical protein	-
FORC89_RS11905	2445083..2445637	+	555	WP_001033796.1	hypothetical protein	-
FORC89_RS11910	2445799..2446128	-	330	WP_001676916.1	DUF977 family protein	-
FORC89_RS11915	2446172..2446219	-	48	Protein_2333	hypothetical protein	-
FORC89_RS11920	2446401..2446868	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
FORC89_RS11925	2447253..2447408	+	156	WP_085981757.1	DUF1391 family protein	-
FORC89_RS11930	2447516..2448037	-	522	WP_000004762.1	super-infection exclusion protein B	-
FORC89_RS11935	2448475..2448696	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2438137..2450008	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T106352 WP_000813254.1 NZ_CP029682:c2443727-2443572 [Salmonella sp. FORC89]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T106352 NZ_CP029682:c2443727-2443572 [Salmonella sp. FORC89]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT106352 NZ_CP029682:2443739-2443797 [Salmonella sp. FORC89]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin