Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2762361..2762878 Replicon chromosome
Accession NZ_CP029681
Organism Staphylococcus aureus strain AR_0473

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag CSC58_RS14385 Protein ID WP_000113262.1
Coordinates 2762612..2762878 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CSC58_RS14380 Protein ID WP_000584499.1
Coordinates 2762361..2762612 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC58_RS14350 2758059..2758778 + 720 WP_000479576.1 amino acid ABC transporter permease -
CSC58_RS14355 2758775..2759506 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
CSC58_RS14360 2759603..2760853 - 1251 WP_001012228.1 FemA/FemB family glycyltransferase FmhA -
CSC58_RS14365 2761108..2761470 + 363 WP_000819843.1 DUF4467 domain-containing protein -
CSC58_RS14370 2761489..2762088 + 600 WP_000162803.1 DsbA family protein -
CSC58_RS14375 2762095..2762196 + 102 Protein_2665 hypothetical protein -
CSC58_RS14380 2762361..2762612 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSC58_RS14385 2762612..2762878 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
CSC58_RS14390 2763172..2764722 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CSC58_RS14395 2764908..2765375 + 468 WP_110179774.1 SRPBCC domain-containing protein -
CSC58_RS14400 2765462..2765644 + 183 WP_000079142.1 hypothetical protein -
CSC58_RS14405 2765861..2766685 + 825 WP_000572040.1 formate/nitrite transporter family protein -
CSC58_RS14410 2766919..2767455 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T106345 WP_000113262.1 NZ_CP029681:2762612-2762878 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T106345 NZ_CP029681:2762612-2762878 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT106345 WP_000584499.1 NZ_CP029681:2762361-2762612 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT106345 NZ_CP029681:2762361-2762612 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References