Detailed information of TA system TA106337

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 848069..848648
• Replicon: chromosome
• Accession: NZ_CP029681
• Organism: Staphylococcus aureus strain AR_0473

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CSC58_RS04790
• Protein ID: WP_001025401.1
• Coordinates: 848069..848314 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	848283..848648 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC58_RS04745	844320..844934	+	615	WP_000191466.1	hypothetical protein	-
CSC58_RS04750	844931..845077	-	147	WP_001795334.1	hypothetical protein	-
CSC58_RS04755	845113..845295	-	183	WP_000705240.1	hypothetical protein	-
CSC58_RS04760	845365..846096	-	732	WP_000511090.1	XRE family transcriptional regulator	-
CSC58_RS04765	846248..846460	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
CSC58_RS04770	846508..846951	+	444	WP_000435357.1	hypothetical protein	-
CSC58_RS14820	846966..847115	+	150	WP_000771849.1	hypothetical protein	-
CSC58_RS04775	847156..847368	-	213	WP_110179735.1	uracil-DNA glycosylase	-
CSC58_RS04780	847438..847635	+	198	WP_001148860.1	hypothetical protein	-
CSC58_RS04785	847622..848002	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
CSC58_RS04790	848069..848314	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CSC58_RS04795	848283..848648	-	366	WP_001128433.1	hypothetical protein	Antitoxin
CSC58_RS04800	848703..848918	+	216	WP_001097552.1	hypothetical protein	-
CSC58_RS04805	848943..849206	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
CSC58_RS04810	849219..849380	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
CSC58_RS04815	849459..849782	+	324	WP_000174998.1	hypothetical protein	-
CSC58_RS04820	849797..850159	+	363	WP_000985972.1	hypothetical protein	-
CSC58_RS04825	850156..851322	+	1167	WP_110179736.1	DUF2800 domain-containing protein	-
CSC58_RS04830	851349..851906	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T106337 WP_001025401.1 NZ_CP029681:848069-848314 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T106337 NZ_CP029681:848069-848314 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT106337 NZ_CP029681:c848648-848283 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin