Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 184377..184639 Replicon chromosome
Accession NZ_CP029681
Organism Staphylococcus aureus strain AR_0473

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag CSC58_RS01020 Protein ID WP_001802298.1
Coordinates 184377..184481 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 184476..184639 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC58_RS00995 181174..181956 + 783 WP_000908189.1 ABC transporter ATP-binding protein -
CSC58_RS01000 182024..182881 + 858 WP_000370928.1 Cof-type HAD-IIB family hydrolase -
CSC58_RS01010 183539..183697 - 159 WP_001792784.1 hypothetical protein -
CSC58_RS14750 183690..183860 - 171 WP_001792292.1 transposase -
CSC58_RS01020 184377..184481 + 105 WP_001802298.1 hypothetical protein Toxin
- 184476..184639 - 164 - - Antitoxin
CSC58_RS01025 184980..186071 - 1092 WP_000495681.1 hypothetical protein -
CSC58_RS01030 186337..187317 - 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
CSC58_RS01035 187319..187639 - 321 WP_000003755.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
CSC58_RS01040 187791..188456 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-115)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T106325 WP_001802298.1 NZ_CP029681:184377-184481 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T106325 NZ_CP029681:184377-184481 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 164 bp

>AT106325 NZ_CP029681:c184639-184476 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References