Detailed information of TA system TA106319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 1386621..1387035
• Replicon: chromosome
• Accession: NZ_CP029680
• Organism: Staphylococcus aureus strain AR_0215

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CSB71_RS07700
• Protein ID: WP_110179692.1
• Coordinates: 1386784..1387035 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CSB71_RS15590
• Protein ID: WP_000028424.1
• Coordinates: 1386621..1386794 (-)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB71_RS07650	1382132..1383409	-	1278	WP_000169945.1	PBSX family phage terminase large subunit	-
CSB71_RS07655	1383396..1383837	-	442	Protein_1374	terminase small subunit	-
CSB71_RS07660	1384024..1384446	-	423	WP_000162696.1	RinA family phage transcriptional activator	-
CSB71_RS07665	1384470..1384616	-	147	WP_000990001.1	hypothetical protein	-
CSB71_RS07670	1384617..1384790	-	174	WP_017804565.1	transcriptional activator RinB	-
CSB71_RS07675	1384787..1385173	-	387	WP_000592201.1	hypothetical protein	-
CSB71_RS07680	1385170..1385376	-	207	WP_000195803.1	DUF1381 domain-containing protein	-
CSB71_RS07685	1385373..1385618	-	246	WP_001282074.1	hypothetical protein	-
CSB71_RS07690	1385655..1386161	-	507	WP_001061842.1	dUTPase	-
CSB71_RS15585	1386176..1386337	-	162	WP_000889682.1	hypothetical protein	-
CSB71_RS07695	1386338..1386595	-	258	WP_000248921.1	hypothetical protein	-
CSB71_RS15590	1386621..1386794	-	174	WP_000028424.1	hypothetical protein	Antitoxin
CSB71_RS07700	1386784..1387035	-	252	WP_110179692.1	DUF1024 family protein	Toxin
CSB71_RS07705	1387050..1387298	-	249	WP_000178987.1	hypothetical protein	-
CSB71_RS07710	1387295..1387552	-	258	WP_000111491.1	DUF3310 domain-containing protein	-
CSB71_RS07715	1387552..1387923	-	372	WP_000101279.1	hypothetical protein	-
CSB71_RS07720	1387936..1388340	-	405	WP_000401969.1	RusA family crossover junction endodeoxyribonuclease	-
CSB71_RS07725	1388349..1388567	-	219	WP_000338528.1	hypothetical protein	-
CSB71_RS07730	1388574..1389458	-	885	WP_000148301.1	DnaD domain protein	-
CSB71_RS07735	1389488..1389958	-	471	WP_031811160.1	single-stranded DNA-binding protein	-
CSB71_RS07740	1389959..1390576	-	618	WP_077517322.1	MBL fold metallo-hydrolase	-
CSB71_RS07745	1390657..1391577	-	921	WP_000138475.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1356530..1400125	43595

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9417.33 Da
• Isoelectric Point: 3.9373

>T106319 WP_110179692.1 NZ_CP029680:c1387035-1386784 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILDGMTNAIQHSVKEGIELDEAVGIMAGQVIYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T106319 NZ_CP029680:c1387035-1386784 [Staphylococcus aureus]
ATGAATAATCGTGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCATTTGATGAAATACTTGATGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGAATTATGGCAGGTCAAGTTATCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT106319 WP_000028424.1 NZ_CP029680:c1386794-1386621 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT106319 NZ_CP029680:c1386794-1386621 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA