Detailed information of TA system TA106316

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 892493..893072
• Replicon: chromosome
• Accession: NZ_CP029680
• Organism: Staphylococcus aureus strain AR_0215

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CSB71_RS05195
• Protein ID: WP_001025401.1
• Coordinates: 892493..892738 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	892707..893072 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB71_RS05150	888744..889358	+	615	WP_000191466.1	hypothetical protein	-
CSB71_RS05155	889355..889501	-	147	WP_001794606.1	hypothetical protein	-
CSB71_RS05160	889537..889719	-	183	WP_000705240.1	hypothetical protein	-
CSB71_RS05165	889789..890520	-	732	WP_000511090.1	XRE family transcriptional regulator	-
CSB71_RS05170	890672..890884	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
CSB71_RS05175	890932..891375	+	444	WP_000435357.1	hypothetical protein	-
CSB71_RS15570	891390..891539	+	150	WP_000771849.1	hypothetical protein	-
CSB71_RS05180	891580..891792	-	213	WP_000362644.1	hypothetical protein	-
CSB71_RS05185	891862..892059	+	198	WP_001148860.1	hypothetical protein	-
CSB71_RS05190	892046..892426	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
CSB71_RS05195	892493..892738	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CSB71_RS05200	892707..893072	-	366	WP_001128433.1	hypothetical protein	Antitoxin
CSB71_RS05205	893127..893342	+	216	WP_001097552.1	hypothetical protein	-
CSB71_RS05210	893367..893630	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
CSB71_RS05215	893643..893804	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
CSB71_RS05220	893883..894206	+	324	WP_000174998.1	hypothetical protein	-
CSB71_RS05225	894221..894583	+	363	WP_000985971.1	hypothetical protein	-
CSB71_RS05230	894580..895746	+	1167	WP_000762538.1	DUF2800 domain-containing protein	-
CSB71_RS05235	895772..896329	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	884424..936557	52133

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T106316 WP_001025401.1 NZ_CP029680:892493-892738 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T106316 NZ_CP029680:892493-892738 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT106316 NZ_CP029680:c893072-892707 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin