Detailed information of TA system TA106301

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2603193..2603377
• Replicon: chromosome
• Accession: NZ_CP029678
• Organism: Staphylococcus aureus strain AR_0216

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: CSB72_RS14060
• Protein ID: WP_000482650.1
• Coordinates: 2603270..2603377 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2603193..2603253 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB72_RS14035	2598723..2598890	-	168	WP_001790576.1	hypothetical protein	-
CSB72_RS14045	2599121..2600854	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
CSB72_RS14050	2600879..2602642	-	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
-	2603193..2603253	+	61	-	-	Antitoxin
CSB72_RS14060	2603270..2603377	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
CSB72_RS14065	2603511..2603897	-	387	WP_000779358.1	flippase GtxA	-
CSB72_RS14070	2604165..2605307	+	1143	WP_001176863.1	glycerate kinase	-
CSB72_RS14075	2605367..2606026	+	660	WP_000831298.1	membrane protein	-
CSB72_RS14080	2606208..2607419	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
CSB72_RS14085	2607542..2608015	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-48)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T106301 WP_000482650.1 NZ_CP029678:c2603377-2603270 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T106301 NZ_CP029678:c2603377-2603270 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT106301 NZ_CP029678:2603193-2603253 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin