Detailed information of TA system TA106296

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2313077..2313356
• Replicon: chromosome
• Accession: NZ_CP029678
• Organism: Staphylococcus aureus strain AR_0216

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: CSB72_RS12475
• Protein ID: WP_001802298.1
• Coordinates: 2313252..2313356 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2313077..2313256 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB72_RS12455	2309276..2309941	-	666	WP_110179730.1	SDR family oxidoreductase	-
CSB72_RS12460	2310093..2310413	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
CSB72_RS12465	2310415..2311395	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
CSB72_RS12470	2311661..2312752	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2313077..2313256	+	180	-	-	Antitoxin
CSB72_RS12475	2313252..2313356	-	105	WP_001802298.1	hypothetical protein	Toxin
CSB72_RS15685	2313517..2314000	-	484	Protein_2270	recombinase family protein	-
CSB72_RS12485	2314043..2315179	-	1137	WP_000115564.1	SAP domain-containing protein	-
CSB72_RS12490	2315468..2315560	+	93	WP_001790138.1	hypothetical protein	-
CSB72_RS12495	2316265..2317122	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
CSB72_RS12500	2317190..2317972	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T106296 WP_001802298.1 NZ_CP029678:c2313356-2313252 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T106296 NZ_CP029678:c2313356-2313252 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 180 bp

>AT106296 NZ_CP029678:2313077-2313256 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin