Detailed information of TA system TA106290

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2138471..2138770
• Replicon: chromosome
• Accession: NZ_CP029678
• Organism: Staphylococcus aureus strain AR_0216

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSB72_RS11450
• Protein ID: WP_011447039.1
• Coordinates: 2138594..2138770 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2138471..2138526 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB72_RS11405	2133802..2134062	+	261	WP_001791826.1	hypothetical protein	-
CSB72_RS11410	2134115..2134465	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSB72_RS11415	2135150..2135599	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CSB72_RS11420	2135694..2136029	-	336	Protein_2071	SH3 domain-containing protein	-
CSB72_RS11430	2136679..2137170	-	492	WP_000919350.1	staphylokinase	-
CSB72_RS11435	2137361..2138116	-	756	WP_000861038.1	CHAP domain-containing protein	-
CSB72_RS11440	2138128..2138382	-	255	WP_000611512.1	phage holin	-
CSB72_RS11445	2138434..2138541	+	108	WP_001791821.1	hypothetical protein	-
-	2138463..2138602	+	140	NuclAT_0	-	-
-	2138463..2138602	+	140	NuclAT_0	-	-
-	2138463..2138602	+	140	NuclAT_0	-	-
-	2138463..2138602	+	140	NuclAT_0	-	-
-	2138471..2138526	+	56	-	-	Antitoxin
CSB72_RS11450	2138594..2138770	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CSB72_RS11455	2138920..2139216	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSB72_RS11460	2139274..2139561	-	288	WP_001040261.1	hypothetical protein	-
CSB72_RS11465	2139608..2139760	-	153	WP_001153681.1	hypothetical protein	-
CSB72_RS11470	2139750..2143535	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2134115..2193082	58967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T106290 WP_011447039.1 NZ_CP029678:c2138770-2138594 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106290 NZ_CP029678:c2138770-2138594 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT106290 NZ_CP029678:2138471-2138526 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin