Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2536414..2536931 Replicon chromosome
Accession NZ_CP029675
Organism Staphylococcus aureus strain AR_0219

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag CSB75_RS13515 Protein ID WP_000113265.1
Coordinates 2536414..2536680 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CSB75_RS13520 Protein ID WP_000584499.1
Coordinates 2536680..2536931 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB75_RS13485 2531842..2532378 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
CSB75_RS13490 2532612..2533436 - 825 WP_000572038.1 formate/nitrite transporter family protein -
CSB75_RS13495 2533653..2533835 - 183 WP_000230292.1 hypothetical protein -
CSB75_RS13500 2533919..2534386 - 468 WP_000153347.1 SRPBCC domain-containing protein -
CSB75_RS13505 2534572..2536119 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CSB75_RS13510 2536308..2536379 - 72 Protein_2466 hypothetical protein -
CSB75_RS13515 2536414..2536680 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
CSB75_RS13520 2536680..2536931 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSB75_RS13525 2537096..2537197 - 102 Protein_2469 hypothetical protein -
CSB75_RS13530 2537204..2537803 - 600 WP_000162810.1 DsbA family protein -
CSB75_RS13535 2537822..2538184 - 363 WP_000819843.1 DUF4467 domain-containing protein -
CSB75_RS13540 2538439..2539689 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
CSB75_RS13545 2539786..2540517 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
CSB75_RS13550 2540514..2541233 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T106282 WP_000113265.1 NZ_CP029675:c2536680-2536414 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T106282 NZ_CP029675:c2536680-2536414 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT106282 WP_000584499.1 NZ_CP029675:c2536931-2536680 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT106282 NZ_CP029675:c2536931-2536680 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References