Detailed information of TA system TA106274

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2087357..2087664
• Replicon: chromosome
• Accession: NZ_CP029675
• Organism: Staphylococcus aureus strain AR_0219

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSB75_RS11000
• Protein ID: WP_011447039.1
• Coordinates: 2087488..2087664 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2087357..2087496 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB75_RS10940	2082924..2083103	+	180	WP_000669791.1	hypothetical protein	-
CSB75_RS10950	2083414..2083674	+	261	WP_001791826.1	hypothetical protein	-
CSB75_RS10955	2083726..2084076	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSB75_RS10960	2084587..2084922	-	336	Protein_1992	SH3 domain-containing protein	-
CSB75_RS10980	2085573..2086064	-	492	WP_000920038.1	staphylokinase	-
CSB75_RS10985	2086279..2087010	-	732	WP_000861035.1	CHAP domain-containing protein	-
CSB75_RS10990	2087022..2087276	-	255	WP_000611512.1	phage holin	-
CSB75_RS10995	2087328..2087435	+	108	WP_031762631.1	hypothetical protein	-
-	2087357..2087496	+	140	NuclAT_0	-	Antitoxin
-	2087357..2087496	+	140	NuclAT_0	-	Antitoxin
-	2087357..2087496	+	140	NuclAT_0	-	Antitoxin
-	2087357..2087496	+	140	NuclAT_0	-	Antitoxin
CSB75_RS11000	2087488..2087664	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CSB75_RS11005	2087773..2088546	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
CSB75_RS11010	2088919..2089293	-	375	WP_000340977.1	hypothetical protein	-
CSB75_RS11015	2089349..2089636	-	288	WP_001262621.1	hypothetical protein	-
CSB75_RS11020	2089682..2089834	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / sell / sec / tsst-1 / groEL	2083726..2150157	66431

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T106274 WP_011447039.1 NZ_CP029675:c2087664-2087488 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106274 NZ_CP029675:c2087664-2087488 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT106274 NZ_CP029675:2087357-2087496 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin