Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2488053..2488570 Replicon chromosome
Accession NZ_CP029673
Organism Staphylococcus aureus strain AR_0220

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag CSB76_RS13105 Protein ID WP_000113265.1
Coordinates 2488053..2488319 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CSB76_RS13110 Protein ID WP_000584499.1
Coordinates 2488319..2488570 (-) Length 84 a.a.

Genomic Context

CSB76_RS13130CSB76_RS13075CSB76_RS13080CSB76_RS13085CSB76_RS13090CSB76_RS13095CSB76_RS13100CSB76_RS13105CSB76_RS13110CSB76_RS13115CSB76_RS13120CSB76_RS13125CSB76_RS13135CSB76_RS13140
Location: 2490078..2491328 (1251 bp)
Type: Others
Protein ID: WP_001012225.1
Location: 2483481..2484017 (537 bp)
Type: Others
Protein ID: WP_000169317.1
Location: 2484251..2485075 (825 bp)
Type: Others
Protein ID: WP_000572038.1
Location: 2485292..2485474 (183 bp)
Type: Others
Protein ID: WP_000230292.1
Location: 2485558..2486025 (468 bp)
Type: Others
Protein ID: WP_000153347.1
Location: 2486211..2487758 (1548 bp)
Type: Others
Protein ID: WP_000727772.1
Location: 2487947..2488018 (72 bp)
Type: Others
Protein ID: Protein_2383
Location: 2488053..2488319 (267 bp)
Type: Toxin
Protein ID: WP_000113265.1
Location: 2488319..2488570 (252 bp)
Type: Antitoxin
Protein ID: WP_000584499.1
Location: 2488735..2488836 (102 bp)
Type: Others
Protein ID: Protein_2386
Location: 2488843..2489442 (600 bp)
Type: Others
Protein ID: WP_000162810.1
Location: 2489461..2489823 (363 bp)
Type: Others
Protein ID: WP_000819843.1
Location: 2491425..2492156 (732 bp)
Type: Others
Protein ID: WP_000615461.1
Location: 2492153..2492872 (720 bp)
Type: Others
Protein ID: WP_000479576.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSB76_RS130752483481..2484017-537WP_000169317.1GNAT family N-acetyltransferase-
CSB76_RS130802484251..2485075-825WP_000572038.1formate/nitrite transporter family protein-
CSB76_RS130852485292..2485474-183WP_000230292.1hypothetical protein-
CSB76_RS130902485558..2486025-468WP_000153347.1SRPBCC domain-containing protein-
CSB76_RS130952486211..2487758-1548WP_000727772.1zinc ABC transporter substrate-binding lipoprotein AdcA-
CSB76_RS131002487947..2488018-72Protein_2383hypothetical protein-
CSB76_RS131052488053..2488319-267WP_000113265.1Txe/YoeB family addiction module toxinToxin
CSB76_RS131102488319..2488570-252WP_000584499.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
CSB76_RS131152488735..2488836-102Protein_2386hypothetical protein-
CSB76_RS131202488843..2489442-600WP_000162810.1DsbA family protein-
CSB76_RS131252489461..2489823-363WP_000819843.1DUF4467 domain-containing protein-
CSB76_RS131302490078..2491328+1251WP_001012225.1FemA/FemB family glycyltransferase FmhA-
CSB76_RS131352491425..2492156-732WP_000615461.1amino acid ABC transporter ATP-binding protein-
CSB76_RS131402492153..2492872-720WP_000479576.1amino acid ABC transporter permease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T106265 WP_000113265.1 NZ_CP029673:c2488319-2488053 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T106265 NZ_CP029673:c2488319-2488053 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT106265 WP_000584499.1 NZ_CP029673:c2488570-2488319 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT106265 NZ_CP029673:c2488570-2488319 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7BWF

Antitoxin

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Source
ID
Structure
PDB6L8G
PDB6L8F
PDB7BWF
PDB6L8E
AlphaFold DBT1YB60

References