Detailed information of TA system TA106246

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2030780..2031058
• Replicon: chromosome
• Accession: NZ_CP029671
• Organism: Staphylococcus aureus strain AR_0222

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: CSB78_RS10345
• Protein ID: WP_001802298.1
• Coordinates: 2030780..2030884 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2030880..2031058 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB78_RS10320	2027577..2028359	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
CSB78_RS10325	2028427..2029284	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
CSB78_RS10335	2029942..2030100	-	159	WP_001792784.1	hypothetical protein	-
CSB78_RS10345	2030780..2030884	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2030880..2031058	-	179	-	-	Antitoxin
CSB78_RS10350	2031317..2032408	-	1092	WP_000495669.1	hypothetical protein	-
CSB78_RS10355	2032674..2033651	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
CSB78_RS10360	2033653..2033973	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
CSB78_RS10365	2034125..2034790	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-266)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T106246 WP_001802298.1 NZ_CP029671:2030780-2030884 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T106246 NZ_CP029671:2030780-2030884 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT106246 NZ_CP029671:c2031058-2030880 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin