Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2030780..2031058 Replicon chromosome
Accession NZ_CP029671
Organism Staphylococcus aureus strain AR_0222

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag CSB78_RS10345 Protein ID WP_001802298.1
Coordinates 2030780..2030884 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2030880..2031058 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB78_RS10320 2027577..2028359 + 783 WP_000908182.1 ABC transporter ATP-binding protein -
CSB78_RS10325 2028427..2029284 + 858 WP_000370925.1 Cof-type HAD-IIB family hydrolase -
CSB78_RS10335 2029942..2030100 - 159 WP_001792784.1 hypothetical protein -
CSB78_RS10345 2030780..2030884 + 105 WP_001802298.1 hypothetical protein Toxin
- 2030880..2031058 - 179 - - Antitoxin
CSB78_RS10350 2031317..2032408 - 1092 WP_000495669.1 hypothetical protein -
CSB78_RS10355 2032674..2033651 - 978 WP_000019734.1 CDF family zinc efflux transporter CzrB -
CSB78_RS10360 2033653..2033973 - 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
CSB78_RS10365 2034125..2034790 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-266)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T106246 WP_001802298.1 NZ_CP029671:2030780-2030884 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T106246 NZ_CP029671:2030780-2030884 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 179 bp

>AT106246 NZ_CP029671:c2031058-2030880 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References