Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1745809..1745993 Replicon chromosome
Accession NZ_CP029671
Organism Staphylococcus aureus strain AR_0222

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag CSB78_RS08785 Protein ID WP_000482652.1
Coordinates 1745809..1745916 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1745933..1745993 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB78_RS08760 1741171..1741644 + 474 WP_000456486.1 GyrI-like domain-containing protein -
CSB78_RS08765 1741767..1742978 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
CSB78_RS08770 1743160..1743819 - 660 WP_000831298.1 membrane protein -
CSB78_RS08775 1743879..1745021 - 1143 WP_001176863.1 glycerate kinase -
CSB78_RS08780 1745289..1745675 + 387 WP_000779360.1 flippase GtxA -
CSB78_RS08785 1745809..1745916 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1745933..1745993 - 61 - - Antitoxin
CSB78_RS08795 1746619..1748382 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
CSB78_RS08800 1748407..1750140 + 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
CSB78_RS08810 1750371..1750538 + 168 Protein_1614 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T106242 WP_000482652.1 NZ_CP029671:1745809-1745916 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T106242 NZ_CP029671:1745809-1745916 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT106242 NZ_CP029671:c1745993-1745933 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References