Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2586780..2587297 Replicon chromosome
Accession NZ_CP029669
Organism Staphylococcus aureus strain AR_0223

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag CSB79_RS13600 Protein ID WP_000113262.1
Coordinates 2587031..2587297 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag CSB79_RS13595 Protein ID WP_000584502.1
Coordinates 2586780..2587031 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB79_RS13565 2582481..2583200 + 720 WP_000479576.1 amino acid ABC transporter permease -
CSB79_RS13570 2583197..2583928 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
CSB79_RS13575 2584025..2585275 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
CSB79_RS13580 2585530..2585889 + 360 WP_000819847.1 DUF4467 domain-containing protein -
CSB79_RS13585 2585908..2586507 + 600 WP_000162813.1 DsbA family protein -
CSB79_RS13590 2586514..2586615 + 102 WP_001791744.1 hypothetical protein -
CSB79_RS13595 2586780..2587031 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSB79_RS13600 2587031..2587297 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
CSB79_RS13605 2587332..2587403 + 72 Protein_2517 hypothetical protein -
CSB79_RS13610 2587592..2589142 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CSB79_RS13615 2589328..2589795 + 468 WP_000153344.1 SRPBCC domain-containing protein -
CSB79_RS13620 2589879..2590061 + 183 WP_000230294.1 hypothetical protein -
CSB79_RS13625 2590278..2591102 + 825 WP_000572040.1 formate/nitrite transporter family protein -
CSB79_RS13630 2591335..2591871 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T106234 WP_000113262.1 NZ_CP029669:2587031-2587297 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T106234 NZ_CP029669:2587031-2587297 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT106234 WP_000584502.1 NZ_CP029669:2586780-2587031 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT106234 NZ_CP029669:2586780-2587031 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References