Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2561956..2562140 Replicon chromosome
Accession NZ_CP029669
Organism Staphylococcus aureus strain AR_0223

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag CSB79_RS13440 Protein ID WP_000482650.1
Coordinates 2561956..2562063 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2562080..2562140 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB79_RS13415 2557318..2557791 + 474 WP_000456489.1 GyrI-like domain-containing protein -
CSB79_RS13420 2557914..2559125 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
CSB79_RS13425 2559307..2559966 - 660 WP_000831298.1 membrane protein -
CSB79_RS13430 2560026..2561168 - 1143 WP_001176863.1 glycerate kinase -
CSB79_RS13435 2561436..2561822 + 387 WP_000779358.1 flippase GtxA -
CSB79_RS13440 2561956..2562063 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2562080..2562140 - 61 - - Antitoxin
CSB79_RS13450 2562691..2564454 + 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
CSB79_RS13455 2564479..2566212 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
CSB79_RS13465 2566443..2566610 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T106232 WP_000482650.1 NZ_CP029669:2561956-2562063 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T106232 NZ_CP029669:2561956-2562063 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT106232 NZ_CP029669:c2562140-2562080 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References