Detailed information of TA system TA106227

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1831436..1831735
• Replicon: chromosome
• Accession: NZ_CP029669
• Organism: Staphylococcus aureus strain AR_0223

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSB79_RS09755
• Protein ID: WP_011447039.1
• Coordinates: 1831559..1831735 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1831436..1831491 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB79_RS09720	1827186..1827278	-	93	WP_001801779.1	hypothetical protein	-
CSB79_RS09725	1827374..1828573	+	1200	WP_000286484.1	NADH-dependent flavin oxidoreductase	-
CSB79_RS09730	1828646..1829473	+	828	WP_000136020.1	alpha/beta hydrolase	-
CSB79_RS09740	1830326..1831081	-	756	WP_000861038.1	CHAP domain-containing protein	-
CSB79_RS09745	1831093..1831347	-	255	WP_000611514.1	phage holin	-
CSB79_RS09750	1831399..1831506	+	108	WP_001791821.1	hypothetical protein	-
-	1831428..1831567	+	140	NuclAT_0	-	-
-	1831428..1831567	+	140	NuclAT_0	-	-
-	1831428..1831567	+	140	NuclAT_0	-	-
-	1831428..1831567	+	140	NuclAT_0	-	-
-	1831436..1831491	+	56	-	-	Antitoxin
CSB79_RS09755	1831559..1831735	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CSB79_RS09760	1831885..1832181	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSB79_RS09765	1832239..1832526	-	288	WP_001040261.1	hypothetical protein	-
CSB79_RS09770	1832573..1832725	-	153	WP_001153681.1	hypothetical protein	-
CSB79_RS09775	1832715..1836500	-	3786	WP_001644870.1	phage minor structural protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	1830326..1880774	50448

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T106227 WP_011447039.1 NZ_CP029669:c1831735-1831559 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106227 NZ_CP029669:c1831735-1831559 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT106227 NZ_CP029669:1831436-1831491 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin