Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 282016..282533 Replicon chromosome
Accession NZ_CP029667
Organism Staphylococcus aureus strain AR_0225

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag CSB81_RS01615 Protein ID WP_000113262.1
Coordinates 282267..282533 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag CSB81_RS01610 Protein ID WP_000584502.1
Coordinates 282016..282267 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB81_RS01580 277717..278436 + 720 WP_000479576.1 amino acid ABC transporter permease -
CSB81_RS01585 278433..279164 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
CSB81_RS01590 279261..280511 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
CSB81_RS01595 280766..281125 + 360 WP_000819847.1 DUF4467 domain-containing protein -
CSB81_RS01600 281144..281743 + 600 WP_000162813.1 DsbA family protein -
CSB81_RS01605 281750..281851 + 102 WP_001791744.1 hypothetical protein -
CSB81_RS01610 282016..282267 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSB81_RS01615 282267..282533 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
CSB81_RS01620 282568..282639 + 72 Protein_270 hypothetical protein -
CSB81_RS01625 282828..284378 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CSB81_RS01630 284564..285031 + 468 WP_000153344.1 SRPBCC domain-containing protein -
CSB81_RS01635 285115..285297 + 183 WP_000230294.1 hypothetical protein -
CSB81_RS01640 285514..286338 + 825 WP_000572040.1 formate/nitrite transporter family protein -
CSB81_RS01645 286571..287107 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T106204 WP_000113262.1 NZ_CP029667:282267-282533 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T106204 NZ_CP029667:282267-282533 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT106204 WP_000584502.1 NZ_CP029667:282016-282267 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT106204 NZ_CP029667:282016-282267 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References