Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 257001..257185 Replicon chromosome
Accession NZ_CP029667
Organism Staphylococcus aureus strain AR_0225

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag CSB81_RS01455 Protein ID WP_000482650.1
Coordinates 257001..257108 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 257125..257185 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB81_RS01430 252363..252836 + 474 WP_000456489.1 GyrI-like domain-containing protein -
CSB81_RS01435 252959..254170 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
CSB81_RS01440 254352..255011 - 660 WP_000831298.1 membrane protein -
CSB81_RS01445 255071..256213 - 1143 WP_001176863.1 glycerate kinase -
CSB81_RS01450 256481..256867 + 387 WP_000779358.1 flippase GtxA -
CSB81_RS01455 257001..257108 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 257125..257185 - 61 - - Antitoxin
CSB81_RS01465 257736..259499 + 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
CSB81_RS01470 259524..261257 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
CSB81_RS01480 261488..261655 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T106202 WP_000482650.1 NZ_CP029667:257001-257108 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T106202 NZ_CP029667:257001-257108 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT106202 NZ_CP029667:c257185-257125 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References