Detailed information of TA system TA106194

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 607074..607412
• Replicon: chromosome
• Accession: NZ_CP029664
• Organism: Staphylococcus aureus strain AR_0226

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSB82_RS03345
• Protein ID: WP_011447039.1
• Coordinates: 607074..607250 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	607238..607412 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB82_RS03325	602309..606094	+	3786	WP_000582165.1	hypothetical protein	-
CSB82_RS03330	606084..606236	+	153	WP_001153681.1	hypothetical protein	-
CSB82_RS03335	606283..606570	+	288	WP_001040261.1	hypothetical protein	-
CSB82_RS03340	606628..606924	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSB82_RS03345	607074..607250	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	607238..607412	-	175	-	-	Antitoxin
CSB82_RS03355	607462..607716	+	255	WP_000611512.1	phage holin	-
CSB82_RS03360	607728..608483	+	756	WP_000861038.1	CHAP domain-containing protein	-
CSB82_RS03365	608674..609165	+	492	WP_000919350.1	staphylokinase	-
CSB82_RS03375	609815..610150	+	336	Protein_628	SH3 domain-containing protein	-
CSB82_RS03380	610245..610694	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CSB82_RS03385	611379..611729	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSB82_RS03390	611782..612042	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn / hlb / map	555781..615544	59763

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T106194 WP_011447039.1 NZ_CP029664:607074-607250 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106194 NZ_CP029664:607074-607250 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT106194 NZ_CP029664:c607412-607238 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin