Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2552837..2553021 Replicon chromosome
Accession NZ_CP029663
Organism Staphylococcus aureus strain AR_0228

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag CSB84_RS13785 Protein ID WP_000482652.1
Coordinates 2552914..2553021 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2552837..2552897 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB84_RS13760 2548292..2548459 - 168 Protein_2483 hypothetical protein -
CSB84_RS13770 2548690..2550423 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
CSB84_RS13775 2550448..2552211 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2552837..2552897 + 61 - - Antitoxin
CSB84_RS13785 2552914..2553021 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
CSB84_RS13790 2553155..2553541 - 387 WP_000779360.1 flippase GtxA -
CSB84_RS13795 2553809..2554951 + 1143 WP_001176863.1 glycerate kinase -
CSB84_RS13800 2555011..2555670 + 660 WP_000831298.1 membrane protein -
CSB84_RS13805 2555852..2557063 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
CSB84_RS13810 2557186..2557659 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T106181 WP_000482652.1 NZ_CP029663:c2553021-2552914 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T106181 NZ_CP029663:c2553021-2552914 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT106181 NZ_CP029663:2552837-2552897 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References