Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2527297..2527814 Replicon chromosome
Accession NZ_CP029663
Organism Staphylococcus aureus strain AR_0228

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag CSB84_RS13625 Protein ID WP_000113265.1
Coordinates 2527297..2527563 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CSB84_RS13630 Protein ID WP_000584499.1
Coordinates 2527563..2527814 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSB84_RS13595 2522725..2523261 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
CSB84_RS13600 2523495..2524319 - 825 WP_000572038.1 formate/nitrite transporter family protein -
CSB84_RS13605 2524536..2524718 - 183 WP_000230292.1 hypothetical protein -
CSB84_RS13610 2524802..2525269 - 468 WP_000153347.1 SRPBCC domain-containing protein -
CSB84_RS13615 2525455..2527002 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CSB84_RS13620 2527191..2527262 - 72 Protein_2458 hypothetical protein -
CSB84_RS13625 2527297..2527563 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
CSB84_RS13630 2527563..2527814 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSB84_RS13635 2527979..2528080 - 102 Protein_2461 hypothetical protein -
CSB84_RS13640 2528087..2528686 - 600 WP_000162810.1 DsbA family protein -
CSB84_RS13645 2528705..2529067 - 363 WP_000819843.1 DUF4467 domain-containing protein -
CSB84_RS13650 2529322..2530572 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
CSB84_RS13655 2530669..2531400 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
CSB84_RS13660 2531397..2532116 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T106180 WP_000113265.1 NZ_CP029663:c2527563-2527297 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T106180 NZ_CP029663:c2527563-2527297 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT106180 WP_000584499.1 NZ_CP029663:c2527814-2527563 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT106180 NZ_CP029663:c2527814-2527563 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References