Detailed information of TA system TA106173

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2096036..2096343
• Replicon: chromosome
• Accession: NZ_CP029663
• Organism: Staphylococcus aureus strain AR_0228

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSB84_RS11225
• Protein ID: WP_011447039.1
• Coordinates: 2096167..2096343 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2096036..2096175 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSB84_RS11175	2091375..2091635	+	261	WP_001791826.1	hypothetical protein	-
CSB84_RS11180	2091688..2092038	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSB84_RS11185	2092723..2093172	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CSB84_RS11190	2093267..2093602	-	336	Protein_2009	SH3 domain-containing protein	-
CSB84_RS11205	2094252..2094743	-	492	WP_000919350.1	staphylokinase	-
CSB84_RS11210	2094934..2095689	-	756	WP_000861038.1	CHAP domain-containing protein	-
CSB84_RS11215	2095701..2095955	-	255	WP_000611512.1	phage holin	-
CSB84_RS11220	2096007..2096114	+	108	WP_001791821.1	hypothetical protein	-
-	2096036..2096175	+	140	NuclAT_0	-	Antitoxin
-	2096036..2096175	+	140	NuclAT_0	-	Antitoxin
-	2096036..2096175	+	140	NuclAT_0	-	Antitoxin
-	2096036..2096175	+	140	NuclAT_0	-	Antitoxin
CSB84_RS11225	2096167..2096343	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CSB84_RS11230	2096493..2096789	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSB84_RS11235	2096847..2097134	-	288	WP_001040261.1	hypothetical protein	-
CSB84_RS11240	2097181..2097333	-	153	WP_001153681.1	hypothetical protein	-
CSB84_RS11245	2097323..2101108	-	3786	WP_000582154.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2091688..2145207	53519

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T106173 WP_011447039.1 NZ_CP029663:c2096343-2096167 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106173 NZ_CP029663:c2096343-2096167 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT106173 NZ_CP029663:2096036-2096175 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin