Detailed information of TA system TA106158

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1442697..1443276
• Replicon: chromosome
• Accession: NZ_CP029658
• Organism: Staphylococcus aureus strain AR_0467

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CSC52_RS07870
• Protein ID: WP_001025401.1
• Coordinates: 1442697..1442942 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1442911..1443276 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC52_RS07830	1438811..1439425	+	615	WP_000191464.1	hypothetical protein	-
CSC52_RS07835	1439422..1439568	-	147	WP_001795334.1	hypothetical protein	-
CSC52_RS07840	1439605..1439787	-	183	WP_000705240.1	hypothetical protein	-
CSC52_RS07845	1439883..1440803	-	921	WP_000348133.1	3'-5' exoribonuclease	-
CSC52_RS07850	1440819..1441433	-	615	WP_000801423.1	XRE family transcriptional regulator	-
CSC52_RS07855	1441605..1441832	+	228	WP_001030311.1	hypothetical protein	-
CSC52_RS07860	1441858..1442413	+	556	Protein_1438	phage antirepressor KilAC domain-containing protein	-
CSC52_RS07865	1442429..1442647	+	219	WP_001001383.1	hypothetical protein	-
CSC52_RS07870	1442697..1442942	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CSC52_RS07875	1442911..1443276	-	366	WP_001128433.1	hypothetical protein	Antitoxin
CSC52_RS07880	1443331..1443546	+	216	WP_001097552.1	hypothetical protein	-
CSC52_RS07885	1443571..1443834	+	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
CSC52_RS07890	1443847..1444008	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
CSC52_RS07895	1444087..1444410	+	324	WP_000174998.1	hypothetical protein	-
CSC52_RS07900	1444425..1444787	+	363	WP_000985971.1	hypothetical protein	-
CSC52_RS07905	1444784..1445956	+	1173	WP_110184199.1	DUF2800 domain-containing protein	-
CSC52_RS07910	1445974..1446527	+	554	Protein_1448	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1434491..1486493	52002

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T106158 WP_001025401.1 NZ_CP029658:1442697-1442942 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T106158 NZ_CP029658:1442697-1442942 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT106158 NZ_CP029658:c1443276-1442911 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTCC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin