Detailed information of TA system TA106152

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 954178..954516
• Replicon: chromosome
• Accession: NZ_CP029658
• Organism: Staphylococcus aureus strain AR_0467

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSC52_RS05110
• Protein ID: WP_011447039.1
• Coordinates: 954178..954354 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	954342..954516 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC52_RS05090	949413..953198	+	3786	WP_000582154.1	hypothetical protein	-
CSC52_RS05095	953188..953340	+	153	WP_031864465.1	hypothetical protein	-
CSC52_RS05100	953387..953674	+	288	WP_001040261.1	hypothetical protein	-
CSC52_RS05105	953732..954028	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSC52_RS05110	954178..954354	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	954342..954516	-	175	-	-	Antitoxin
CSC52_RS05120	954566..954820	+	255	WP_000611512.1	phage holin	-
CSC52_RS05125	954832..955587	+	756	WP_000861038.1	CHAP domain-containing protein	-
CSC52_RS05130	955778..956269	+	492	WP_000919350.1	staphylokinase	-
CSC52_RS05145	956919..957254	+	336	Protein_956	SH3 domain-containing protein	-
CSC52_RS05150	957349..957798	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CSC52_RS05155	958483..958833	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSC52_RS05160	958886..959146	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	905314..958833	53519

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T106152 WP_011447039.1 NZ_CP029658:954178-954354 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106152 NZ_CP029658:954178-954354 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT106152 NZ_CP029658:c954516-954342 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin