Detailed information of TA system TA106132

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2095049..2095348
• Replicon: chromosome
• Accession: NZ_CP029657
• Organism: Staphylococcus aureus strain AR_0468

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSC53_RS11050
• Protein ID: WP_011447039.1
• Coordinates: 2095172..2095348 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2095049..2095104 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC53_RS11000	2090380..2090640	+	261	WP_001791826.1	hypothetical protein	-
CSC53_RS11005	2090693..2091043	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSC53_RS11010	2091728..2092177	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CSC53_RS11015	2092272..2092607	-	336	Protein_2005	SH3 domain-containing protein	-
CSC53_RS11030	2093257..2093748	-	492	WP_000919350.1	staphylokinase	-
CSC53_RS11035	2093939..2094694	-	756	WP_000861038.1	CHAP domain-containing protein	-
CSC53_RS11040	2094706..2094960	-	255	WP_000611512.1	phage holin	-
CSC53_RS11045	2095012..2095119	+	108	WP_001791821.1	hypothetical protein	-
-	2095041..2095180	+	140	NuclAT_0	-	-
-	2095041..2095180	+	140	NuclAT_0	-	-
-	2095041..2095180	+	140	NuclAT_0	-	-
-	2095041..2095180	+	140	NuclAT_0	-	-
-	2095049..2095104	+	56	-	-	Antitoxin
CSC53_RS11050	2095172..2095348	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CSC53_RS11055	2095498..2095794	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSC53_RS11060	2095852..2096139	-	288	WP_001040261.1	hypothetical protein	-
CSC53_RS11065	2096186..2096338	-	153	WP_031864465.1	hypothetical protein	-
CSC53_RS11070	2096328..2100113	-	3786	WP_000582154.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2090693..2144212	53519

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T106132 WP_011447039.1 NZ_CP029657:c2095348-2095172 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106132 NZ_CP029657:c2095348-2095172 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT106132 NZ_CP029657:2095049-2095104 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin