Detailed information of TA system TA106125

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1606141..1606720
• Replicon: chromosome
• Accession: NZ_CP029657
• Organism: Staphylococcus aureus strain AR_0468

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CSC53_RS08305
• Protein ID: WP_001025401.1
• Coordinates: 1606475..1606720 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1606141..1606506 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC53_RS08265	1602884..1603441	-	558	WP_000645048.1	DUF2815 family protein	-
CSC53_RS08270	1603467..1604633	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
CSC53_RS08275	1604630..1604992	-	363	WP_000985971.1	hypothetical protein	-
CSC53_RS08280	1605007..1605330	-	324	WP_000174998.1	hypothetical protein	-
CSC53_RS08285	1605409..1605570	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
CSC53_RS08290	1605583..1605846	-	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
CSC53_RS08295	1605871..1606086	-	216	WP_001097552.1	hypothetical protein	-
CSC53_RS08300	1606141..1606506	+	366	WP_001128433.1	hypothetical protein	Antitoxin
CSC53_RS08305	1606475..1606720	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CSC53_RS08310	1606770..1606988	-	219	WP_001001383.1	hypothetical protein	-
CSC53_RS08315	1607004..1607559	-	556	Protein_1524	phage antirepressor KilAC domain-containing protein	-
CSC53_RS08320	1607585..1607812	-	228	WP_001030311.1	hypothetical protein	-
CSC53_RS08325	1607984..1608598	+	615	WP_000801423.1	XRE family transcriptional regulator	-
CSC53_RS08330	1608614..1609534	+	921	WP_000348133.1	3'-5' exoribonuclease	-
CSC53_RS08335	1609630..1609812	+	183	WP_000705240.1	hypothetical protein	-
CSC53_RS08340	1609849..1609995	+	147	WP_001795334.1	hypothetical protein	-
CSC53_RS08345	1609992..1610606	-	615	WP_000191464.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1566204..1629562	63358

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T106125 WP_001025401.1 NZ_CP029657:c1606720-1606475 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T106125 NZ_CP029657:c1606720-1606475 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT106125 NZ_CP029657:1606141-1606506 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin