Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 916849..917033 Replicon chromosome
Accession NZ_CP029655
Organism Staphylococcus aureus strain AR_0469

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag CSC54_RS04675 Protein ID WP_000482652.1
Coordinates 916849..916956 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 916973..917033 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC54_RS04650 912211..912684 + 474 WP_000456486.1 GyrI-like domain-containing protein -
CSC54_RS04655 912807..914018 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
CSC54_RS04660 914200..914859 - 660 WP_000831298.1 membrane protein -
CSC54_RS04665 914919..916061 - 1143 WP_001176863.1 glycerate kinase -
CSC54_RS04670 916329..916715 + 387 WP_000779360.1 flippase GtxA -
CSC54_RS04675 916849..916956 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 916973..917033 - 61 - - Antitoxin
CSC54_RS04685 917659..919422 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
CSC54_RS04690 919447..921180 + 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
CSC54_RS04700 921411..921578 + 168 Protein_838 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T106111 WP_000482652.1 NZ_CP029655:916849-916956 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T106111 NZ_CP029655:916849-916956 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT106111 NZ_CP029655:c917033-916973 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References