Detailed information of TA system TA106097

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2186788..2187095
• Replicon: chromosome
• Accession: NZ_CP029653
• Organism: Staphylococcus aureus strain AR_0470

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSC55_RS11145
• Protein ID: WP_011447039.1
• Coordinates: 2186919..2187095 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2186788..2186927 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC55_RS11095	2182129..2182389	+	261	WP_001791826.1	hypothetical protein	-
CSC55_RS11100	2182442..2182792	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
CSC55_RS11105	2183475..2183924	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
CSC55_RS11110	2184019..2184353	-	335	Protein_2072	SH3 domain-containing protein	-
CSC55_RS11125	2185004..2185495	-	492	WP_000920042.1	staphylokinase	-
CSC55_RS11130	2185686..2186441	-	756	WP_000861026.1	CHAP domain-containing protein	-
CSC55_RS11135	2186453..2186707	-	255	WP_000611512.1	phage holin	-
CSC55_RS11140	2186759..2186866	+	108	WP_031762631.1	hypothetical protein	-
-	2186788..2186927	+	140	NuclAT_0	-	Antitoxin
-	2186788..2186927	+	140	NuclAT_0	-	Antitoxin
-	2186788..2186927	+	140	NuclAT_0	-	Antitoxin
-	2186788..2186927	+	140	NuclAT_0	-	Antitoxin
CSC55_RS11145	2186919..2187095	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CSC55_RS11150	2187298..2188071	-	774	WP_025174055.1	staphylococcal enterotoxin type P	-
CSC55_RS11155	2188492..2188866	-	375	WP_000340977.1	hypothetical protein	-
CSC55_RS11160	2188922..2189209	-	288	WP_001262621.1	hypothetical protein	-
CSC55_RS11165	2189255..2189407	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	blaZ	hlb / scn / chp / sak / see / hlb / groEL / hld	2134435..2265731	131296

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T106097 WP_011447039.1 NZ_CP029653:c2187095-2186919 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106097 NZ_CP029653:c2187095-2186919 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT106097 NZ_CP029653:2186788-2186927 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin