Detailed information of TA system TA106094

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2021949..2022129
• Replicon: chromosome
• Accession: NZ_CP029653
• Organism: Staphylococcus aureus strain AR_0470

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: CSC55_RS10095
• Protein ID: WP_001801861.1
• Coordinates: 2021949..2022044 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2022072..2022129 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC55_RS10060	2017094..2017720	+	627	WP_000669038.1	hypothetical protein	-
CSC55_RS10065	2017761..2018105	+	345	WP_000627550.1	DUF3969 family protein	-
CSC55_RS10070	2018203..2018775	+	573	WP_000414222.1	hypothetical protein	-
CSC55_RS10075	2018924..2020291	-	1368	WP_001093574.1	FRG domain-containing protein	-
CSC55_RS10080	2020291..2020860	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
CSC55_RS10085	2021053..2021499	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
CSC55_RS10095	2021949..2022044	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2022072..2022129	-	58	-	-	Antitoxin
CSC55_RS10100	2022167..2022268	+	102	WP_001791232.1	hypothetical protein	-
CSC55_RS10105	2022443..2022886	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
CSC55_RS10110	2022886..2023329	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
CSC55_RS10115	2023329..2023771	-	443	Protein_1917	DUF1433 domain-containing protein	-
CSC55_RS10120	2024296..2026716	+	2421	WP_033844720.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T106094 WP_001801861.1 NZ_CP029653:2021949-2022044 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T106094 NZ_CP029653:2021949-2022044 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT106094 NZ_CP029653:c2022129-2022072 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin