Detailed information of TA system TA106090

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 2459397..2459704
• Replicon: chromosome
• Accession: NZ_CP029652
• Organism: Staphylococcus aureus strain AR_0471

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSC56_RS12795
• Protein ID: WP_011447039.1
• Coordinates: 2459397..2459573 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2459563..2459704 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC56_RS12775	2454632..2458417	+	3786	WP_000582165.1	hypothetical protein	-
CSC56_RS12780	2458407..2458559	+	153	WP_001153681.1	hypothetical protein	-
CSC56_RS12785	2458606..2458893	+	288	WP_001040261.1	hypothetical protein	-
CSC56_RS12790	2458951..2459247	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSC56_RS12795	2459397..2459573	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	2459563..2459704	-	142	-	-	Antitoxin
CSC56_RS12805	2459785..2460039	+	255	WP_000611512.1	phage holin	-
CSC56_RS12810	2460051..2460806	+	756	WP_000861038.1	CHAP domain-containing protein	-
CSC56_RS12815	2460997..2461488	+	492	WP_000919350.1	staphylokinase	-
CSC56_RS12825	2462138..2462473	+	336	Protein_2372	SH3 domain-containing protein	-
CSC56_RS12830	2462568..2463017	-	450	WP_103152000.1	chemotaxis-inhibiting protein CHIPS	-
CSC56_RS12835	2463702..2464052	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSC56_RS12840	2464105..2464365	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sak / chp / scn / hlb / map	2419498..2467771	48273

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T106090 WP_011447039.1 NZ_CP029652:2459397-2459573 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106090 NZ_CP029652:2459397-2459573 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 142 bp

>AT106090 NZ_CP029652:c2459704-2459563 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin