Detailed information of TA system TA106075

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2566069..2566407
• Replicon: chromosome
• Accession: NZ_CP029649
• Organism: Staphylococcus aureus strain AR_0472

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: CSC57_RS13155
• Protein ID: WP_072353918.1
• Coordinates: 2566069..2566245 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2566233..2566407 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC57_RS13135	2561236..2565018	+	3783	WP_031806961.1	phage minor structural protein	-
CSC57_RS13140	2565011..2565163	+	153	WP_001000058.1	hypothetical protein	-
CSC57_RS13145	2565209..2565496	+	288	WP_001262620.1	hypothetical protein	-
CSC57_RS13150	2565552..2565926	+	375	WP_000340977.1	hypothetical protein	-
CSC57_RS13155	2566069..2566245	+	177	WP_072353918.1	putative holin-like toxin	Toxin
-	2566233..2566407	-	175	-	-	Antitoxin
CSC57_RS13165	2566457..2566711	+	255	WP_000611512.1	phage holin	-
CSC57_RS13170	2566723..2567478	+	756	WP_000861038.1	CHAP domain-containing protein	-
CSC57_RS13175	2567669..2568160	+	492	WP_000919350.1	staphylokinase	-
CSC57_RS13185	2568810..2569145	+	336	Protein_2476	SH3 domain-containing protein	-
CSC57_RS13190	2569240..2569689	-	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
CSC57_RS13195	2570371..2570721	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
CSC57_RS13200	2570774..2571034	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	blaZ	hld / groEL / hlb / sak / chp / scn / hlb / map	2488488..2619096	130608

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T106075 WP_072353918.1 NZ_CP029649:2566069-2566245 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T106075 NZ_CP029649:2566069-2566245 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT106075 NZ_CP029649:c2566407-2566233 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin