Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2136298..2136815 Replicon chromosome
Accession NZ_CP029649
Organism Staphylococcus aureus strain AR_0472

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag CSC57_RS10780 Protein ID WP_000113262.1
Coordinates 2136549..2136815 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CSC57_RS10775 Protein ID WP_000584499.1
Coordinates 2136298..2136549 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC57_RS10745 2131996..2132715 + 720 WP_000479576.1 amino acid ABC transporter permease -
CSC57_RS10750 2132712..2133443 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
CSC57_RS10755 2133540..2134790 - 1251 WP_001012228.1 FemA/FemB family glycyltransferase FmhA -
CSC57_RS10760 2135045..2135407 + 363 WP_000819843.1 DUF4467 domain-containing protein -
CSC57_RS10765 2135426..2136025 + 600 WP_000162803.1 DsbA family protein -
CSC57_RS10770 2136032..2136133 + 102 Protein_2026 hypothetical protein -
CSC57_RS10775 2136298..2136549 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSC57_RS10780 2136549..2136815 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
CSC57_RS10785 2137109..2138659 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
CSC57_RS10790 2138845..2139312 + 468 WP_110179774.1 SRPBCC domain-containing protein -
CSC57_RS10795 2139399..2139581 + 183 WP_000079142.1 hypothetical protein -
CSC57_RS10800 2139798..2140622 + 825 WP_000572040.1 formate/nitrite transporter family protein -
CSC57_RS10805 2140856..2141392 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T106068 WP_000113262.1 NZ_CP029649:2136549-2136815 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T106068 NZ_CP029649:2136549-2136815 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT106068 WP_000584499.1 NZ_CP029649:2136298-2136549 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT106068 NZ_CP029649:2136298-2136549 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References