Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2136298..2136815 Replicon chromosome
Accession NZ_CP029649
Organism Staphylococcus aureus strain AR_0472

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag CSC57_RS10780 Protein ID WP_000113262.1
Coordinates 2136549..2136815 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag CSC57_RS10775 Protein ID WP_000584499.1
Coordinates 2136298..2136549 (+) Length 84 a.a.

Genomic Context


CSC57_RS10745CSC57_RS10750CSC57_RS10760CSC57_RS10765CSC57_RS10770CSC57_RS10775CSC57_RS10780CSC57_RS10785CSC57_RS10790CSC57_RS10795CSC57_RS10800CSC57_RS10805CSC57_RS10755
Location: 2131996..2132715 (720 bp)
Type: Others
Protein ID: WP_000479576.1
Location: 2132712..2133443 (732 bp)
Type: Others
Protein ID: WP_000615461.1
Location: 2135045..2135407 (363 bp)
Type: Others
Protein ID: WP_000819843.1
Location: 2135426..2136025 (600 bp)
Type: Others
Protein ID: WP_000162803.1
Location: 2136032..2136133 (102 bp)
Type: Others
Protein ID: Protein_2026
Location: 2136298..2136549 (252 bp)
Type: Antitoxin
Protein ID: WP_000584499.1
Location: 2136549..2136815 (267 bp)
Type: Toxin
Protein ID: WP_000113262.1
Location: 2137109..2138659 (1551 bp)
Type: Others
Protein ID: WP_000727763.1
Location: 2138845..2139312 (468 bp)
Type: Others
Protein ID: WP_110179774.1
Location: 2139399..2139581 (183 bp)
Type: Others
Protein ID: WP_000079142.1
Location: 2139798..2140622 (825 bp)
Type: Others
Protein ID: WP_000572040.1
Location: 2140856..2141392 (537 bp)
Type: Others
Protein ID: WP_000169317.1
Location: 2133540..2134790 (1251 bp)
Type: Others
Protein ID: WP_001012228.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSC57_RS107452131996..2132715+720WP_000479576.1amino acid ABC transporter permease-
CSC57_RS107502132712..2133443+732WP_000615461.1amino acid ABC transporter ATP-binding protein-
CSC57_RS107552133540..2134790-1251WP_001012228.1FemA/FemB family glycyltransferase FmhA-
CSC57_RS107602135045..2135407+363WP_000819843.1DUF4467 domain-containing protein-
CSC57_RS107652135426..2136025+600WP_000162803.1DsbA family protein-
CSC57_RS107702136032..2136133+102Protein_2026hypothetical protein-
CSC57_RS107752136298..2136549+252WP_000584499.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
CSC57_RS107802136549..2136815+267WP_000113262.1Txe/YoeB family addiction module toxinToxin
CSC57_RS107852137109..2138659+1551WP_000727763.1zinc ABC transporter substrate-binding lipoprotein AdcA-
CSC57_RS107902138845..2139312+468WP_110179774.1SRPBCC domain-containing protein-
CSC57_RS107952139399..2139581+183WP_000079142.1hypothetical protein-
CSC57_RS108002139798..2140622+825WP_000572040.1formate/nitrite transporter family protein-
CSC57_RS108052140856..2141392+537WP_000169317.1GNAT family N-acetyltransferase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T106068 WP_000113262.1 NZ_CP029649:2136549-2136815 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T106068 NZ_CP029649:2136549-2136815 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT106068 WP_000584499.1 NZ_CP029649:2136298-2136549 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT106068 NZ_CP029649:2136298-2136549 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
PDB6L8G
PDB6L8F
PDB7CUA
PDB6L8E


Antitoxin

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Source
ID
Structure
PDB6L8G
PDB6L8F
PDB7BWF
PDB6L8E
AlphaFold DBT1YB60

References