Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2111258..2111442 Replicon chromosome
Accession NZ_CP029649
Organism Staphylococcus aureus strain AR_0472

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag CSC57_RS10620 Protein ID WP_000482650.1
Coordinates 2111258..2111365 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2111382..2111442 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC57_RS10595 2106630..2107103 + 474 WP_000456489.1 GyrI-like domain-containing protein -
CSC57_RS10600 2107226..2108437 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
CSC57_RS10605 2108619..2109278 - 660 WP_000831298.1 membrane protein -
CSC57_RS10610 2109338..2110480 - 1143 WP_001176863.1 glycerate kinase -
CSC57_RS10615 2110738..2111124 + 387 WP_000779358.1 flippase GtxA -
CSC57_RS10620 2111258..2111365 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2111382..2111442 - 61 - - Antitoxin
CSC57_RS10630 2112013..2113776 + 1764 WP_001064820.1 ABC transporter ATP-binding protein/permease -
CSC57_RS10635 2113801..2115534 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
CSC57_RS10645 2115765..2115932 + 168 WP_001792506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T106066 WP_000482650.1 NZ_CP029649:2111258-2111365 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T106066 NZ_CP029649:2111258-2111365 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT106066 NZ_CP029649:c2111442-2111382 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References