Detailed information of TA system TA106060

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 222001..222580
• Replicon: chromosome
• Accession: NZ_CP029649
• Organism: Staphylococcus aureus strain AR_0472

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CSC57_RS01190
• Protein ID: WP_001025401.1
• Coordinates: 222001..222246 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	222215..222580 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC57_RS01145	218252..218866	+	615	WP_000191466.1	hypothetical protein	-
CSC57_RS01150	218863..219009	-	147	WP_001795334.1	hypothetical protein	-
CSC57_RS01155	219045..219227	-	183	WP_000705240.1	hypothetical protein	-
CSC57_RS01160	219297..220028	-	732	WP_000511090.1	XRE family transcriptional regulator	-
CSC57_RS01165	220180..220392	+	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
CSC57_RS01170	220440..220883	+	444	WP_000435357.1	hypothetical protein	-
CSC57_RS14820	220898..221047	+	150	WP_000771849.1	hypothetical protein	-
CSC57_RS01175	221088..221300	-	213	WP_110179735.1	uracil-DNA glycosylase	-
CSC57_RS01180	221370..221567	+	198	WP_001148860.1	hypothetical protein	-
CSC57_RS01185	221554..221934	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
CSC57_RS01190	222001..222246	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CSC57_RS01195	222215..222580	-	366	WP_001128433.1	hypothetical protein	Antitoxin
CSC57_RS01200	222635..222850	+	216	WP_001097552.1	hypothetical protein	-
CSC57_RS01205	222875..223138	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
CSC57_RS01210	223151..223312	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
CSC57_RS01215	223391..223714	+	324	WP_000174998.1	hypothetical protein	-
CSC57_RS01220	223729..224091	+	363	WP_000985972.1	hypothetical protein	-
CSC57_RS01225	224088..225254	+	1167	WP_110179736.1	DUF2800 domain-containing protein	-
CSC57_RS01230	225281..225838	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T106060 WP_001025401.1 NZ_CP029649:222001-222246 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T106060 NZ_CP029649:222001-222246 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT106060 NZ_CP029649:c222580-222215 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin