Detailed information of TA system TA106053

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2524133..2524632
• Replicon: chromosome
• Accession: NZ_CP029629
• Organism: Staphylococcus aureus strain MOK063

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: DLJ56_RS13140
• Protein ID: WP_000074044.1
• Coordinates: 2524133..2524375 (-)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: DLJ56_RS13145
• Protein ID: WP_000587618.1
• Coordinates: 2524375..2524632 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ56_RS13120	2519438..2520625	-	1188	WP_110161708.1	MFS transporter	-
DLJ56_RS13125	2521021..2521797	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
DLJ56_RS13130	2521790..2522452	-	663	WP_000923523.1	ATP-binding cassette domain-containing protein	-
DLJ56_RS13135	2522700..2523776	-	1077	WP_001076672.1	M42 family metallopeptidase	-
DLJ56_RS13140	2524133..2524375	-	243	WP_000074044.1	Txe/YoeB family addiction module toxin	Toxin
DLJ56_RS13145	2524375..2524632	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DLJ56_RS13155	2524991..2525446	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
DLJ56_RS13160	2525614..2527190	-	1577	Protein_2428	FMN-binding glutamate synthase family protein	-
DLJ56_RS13165	2527385..2528134	+	750	WP_000072459.1	hypothetical protein	-
DLJ56_RS13170	2528365..2529558	-	1194	WP_000675411.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-79)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9649.18 Da
• Isoelectric Point: 10.1469

>T106053 WP_000074044.1 NZ_CP029629:c2524375-2524133 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Nucleotide

• Length: 243 bp

>T106053 NZ_CP029629:c2524375-2524133 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAGACATTTATAGAAATTGTTGAGACTTT
AAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATTTAGAGCGATATTCAAGAAGAATTA
ACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATACTATCGGCATGGTCACATTATGAT
TAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT106053 WP_000587618.1 NZ_CP029629:c2524632-2524375 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT106053 NZ_CP029629:c2524632-2524375 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: T1YBB2