Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2465691..2466208 Replicon chromosome
Accession NZ_CP029629
Organism Staphylococcus aureus strain MOK063

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag DLJ56_RS12815 Protein ID WP_000113262.1
Coordinates 2465691..2465957 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag DLJ56_RS12820 Protein ID WP_000584501.1
Coordinates 2465957..2466208 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ56_RS12790 2461109..2461645 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
DLJ56_RS12795 2461879..2462703 - 825 WP_000572040.1 formate/nitrite transporter family protein -
DLJ56_RS12800 2462920..2463102 - 183 WP_000079142.1 hypothetical protein -
DLJ56_RS12805 2463189..2463656 - 468 WP_000153344.1 SRPBCC domain-containing protein -
DLJ56_RS12810 2463842..2465395 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
DLJ56_RS12815 2465691..2465957 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
DLJ56_RS12820 2465957..2466208 - 252 WP_000584501.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DLJ56_RS12825 2466373..2466474 - 102 WP_031774922.1 hypothetical protein -
DLJ56_RS12830 2466481..2467080 - 600 WP_000162813.1 DsbA family protein -
DLJ56_RS12835 2467099..2467461 - 363 WP_110161706.1 DUF4467 domain-containing protein -
DLJ56_RS12840 2467716..2468966 + 1251 WP_001012223.1 FemA/FemB family glycyltransferase FmhA -
DLJ56_RS12845 2469045..2470364 - 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2469045..2470364 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T106050 WP_000113262.1 NZ_CP029629:c2465957-2465691 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T106050 NZ_CP029629:c2465957-2465691 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9406.58 Da        Isoelectric Point: 4.3407

>AT106050 WP_000584501.1 NZ_CP029629:c2466208-2465957 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPSNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT106050 NZ_CP029629:c2466208-2465957 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAGTAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure

References