Detailed information of TA system TA106045

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2567988..2568487
• Replicon: chromosome
• Accession: NZ_CP029627
• Organism: Staphylococcus aureus strain MOK042

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: DLJ55_RS13525
• Protein ID: WP_000074044.1
• Coordinates: 2567988..2568230 (-)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: DLJ55_RS13530
• Protein ID: WP_000587618.1
• Coordinates: 2568230..2568487 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ55_RS13505	2563293..2564480	-	1188	WP_000026189.1	MFS transporter	-
DLJ55_RS13510	2564876..2565652	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
DLJ55_RS13515	2565645..2566307	-	663	WP_000923523.1	ATP-binding cassette domain-containing protein	-
DLJ55_RS13520	2566555..2567631	-	1077	WP_001076672.1	M42 family metallopeptidase	-
DLJ55_RS13525	2567988..2568230	-	243	WP_000074044.1	Txe/YoeB family addiction module toxin	Toxin
DLJ55_RS13530	2568230..2568487	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DLJ55_RS13540	2568846..2569301	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
DLJ55_RS13545	2569469..2571045	-	1577	Protein_2501	FMN-binding glutamate synthase family protein	-
DLJ55_RS13550	2571240..2571989	+	750	WP_000072459.1	hypothetical protein	-
DLJ55_RS13555	2572220..2573413	-	1194	WP_000675411.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-79)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 9649.18 Da
• Isoelectric Point: 10.1469

>T106045 WP_000074044.1 NZ_CP029627:c2568230-2567988 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLILSAWSHYD

Nucleotide

• Length: 243 bp

>T106045 NZ_CP029627:c2568230-2567988 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAGACATTTATAGAAATTGTTGAGACTTT
AAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATTTAGAGCGATATTCAAGAAGAATTA
ACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATACTATCGGCATGGTCACATTATGAT
TAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT106045 WP_000587618.1 NZ_CP029627:c2568487-2568230 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT106045 NZ_CP029627:c2568487-2568230 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Antitoxin

• AlphaFold DB: T1YBB2