Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1248693..1249107 Replicon chromosome
Accession NZ_CP029627
Organism Staphylococcus aureus strain MOK042

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DLJ55_RS06510 Protein ID WP_110166336.1
Coordinates 1248693..1248944 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DLJ55_RS15110 Protein ID WP_000028424.1
Coordinates 1248934..1249107 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ55_RS06445 1243943..1244728 + 786 WP_000443353.1 ATP-binding protein -
DLJ55_RS06450 1244725..1244883 + 159 WP_000628837.1 hypothetical protein -
DLJ55_RS06455 1244896..1245117 + 222 WP_001123685.1 DUF3269 family protein -
DLJ55_RS06460 1245128..1245532 + 405 WP_000049801.1 DUF1064 domain-containing protein -
DLJ55_RS06465 1245537..1245722 + 186 WP_001187254.1 DUF3113 family protein -
DLJ55_RS06470 1245723..1246232 + 510 WP_070045555.1 hypothetical protein -
DLJ55_RS06475 1246232..1246486 + 255 WP_000022736.1 DUF3310 domain-containing protein -
DLJ55_RS06480 1246486..1246734 + 249 WP_060474161.1 hypothetical protein -
DLJ55_RS06485 1246748..1246954 + 207 WP_000693989.1 hypothetical protein -
DLJ55_RS06490 1246957..1247361 + 405 WP_000695756.1 hypothetical protein -
DLJ55_RS06495 1247358..1247552 + 195 WP_000983953.1 hypothetical protein -
DLJ55_RS06500 1247549..1248001 + 453 WP_000982706.1 hypothetical protein -
DLJ55_RS06505 1247998..1248501 + 504 WP_110166335.1 hypothetical protein -
DLJ55_RS06510 1248693..1248944 + 252 WP_110166336.1 DUF1024 family protein Toxin
DLJ55_RS15110 1248934..1249107 + 174 WP_000028424.1 hypothetical protein Antitoxin
DLJ55_RS06515 1249108..1249389 + 282 WP_000454994.1 hypothetical protein -
DLJ55_RS15115 1249390..1249551 + 162 WP_000889683.1 hypothetical protein -
DLJ55_RS06520 1249566..1250099 + 534 WP_025920701.1 dUTP diphosphatase -
DLJ55_RS06525 1250136..1250330 + 195 WP_110166337.1 DUF1381 domain-containing protein -
DLJ55_RS06530 1250327..1250530 + 204 WP_001072795.1 hypothetical protein -
DLJ55_RS06535 1250523..1250759 + 237 WP_000608281.1 hypothetical protein -
DLJ55_RS06540 1250749..1251138 + 390 WP_001568228.1 hypothetical protein -
DLJ55_RS06545 1251135..1251308 + 174 WP_000595257.1 transcriptional activator RinB -
DLJ55_RS06550 1251309..1251710 + 402 WP_000286968.1 hypothetical protein -
DLJ55_RS06560 1252063..1252557 + 495 WP_000594088.1 terminase small subunit -
DLJ55_RS06565 1252550..1253773 + 1224 WP_001037586.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9445.35 Da        Isoelectric Point: 3.9476

>T106038 WP_110166336.1 NZ_CP029627:1248693-1248944 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T106038 NZ_CP029627:1248693-1248944 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAGAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTGGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT106038 WP_000028424.1 NZ_CP029627:1248934-1249107 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT106038 NZ_CP029627:1248934-1249107 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AAGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References