Detailed information of TA system TA106021

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2872195..2872479
• Replicon: chromosome
• Accession: NZ_CP029612
• Organism: Enterococcus faecalis strain H25

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: CNQ40_RS15225
• Protein ID: WP_002386265.1
• Coordinates: 2872351..2872479 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2872195..2872402 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNQ40_RS15200	2867880..2868833	-	954	WP_002361029.1	siderophore ABC transporter substrate-binding protein	-
CNQ40_RS15205	2868872..2869627	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
CNQ40_RS15210	2869624..2870589	-	966	WP_002367415.1	iron chelate uptake ABC transporter family permease subunit	-
CNQ40_RS15215	2870586..2871533	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
CNQ40_RS15220	2871717..2872169	+	453	WP_002359057.1	YueI family protein	-
-	2872195..2872402	+	208	-	-	Antitoxin
CNQ40_RS15225	2872351..2872479	-	129	WP_002386265.1	hypothetical protein	Toxin
CNQ40_RS15230	2872785..2872912	-	128	Protein_2812	putative holin-like toxin	-
CNQ40_RS15235	2873074..2875344	-	2271	WP_002380953.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
CNQ40_RS15240	2875515..2876015	+	501	WP_002380954.1	cysteine hydrolase	-
CNQ40_RS15245	2876467..2877363	+	897	WP_095714896.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4742.66 Da
• Isoelectric Point: 7.0058

>T106021 WP_002386265.1 NZ_CP029612:c2872479-2872351 [Enterococcus faecalis]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 129 bp

>T106021 NZ_CP029612:c2872479-2872351 [Enterococcus faecalis]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 208 bp

>AT106021 NZ_CP029612:2872195-2872402 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATAAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin