Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 137409..138428 Replicon chromosome
Accession NZ_CP029612
Organism Enterococcus faecalis strain H25

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag CNQ40_RS00640 Protein ID WP_002414854.1
Coordinates 137409..138047 (-) Length 213 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag CNQ40_RS00645 Protein ID WP_002414856.1
Coordinates 138054..138428 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ40_RS00615 132482..134833 - 2352 WP_002370637.1 C39 family peptidase -
CNQ40_RS00620 134936..135265 - 330 WP_002399673.1 hypothetical protein -
CNQ40_RS00630 135592..136209 + 618 WP_002387485.1 hypothetical protein -
CNQ40_RS00635 136792..137367 + 576 WP_010775494.1 restriction endonuclease -
CNQ40_RS00640 137409..138047 - 639 WP_002414854.1 ImmA/IrrE family metallo-endopeptidase Toxin
CNQ40_RS00645 138054..138428 - 375 WP_002414856.1 helix-turn-helix domain-containing protein Antitoxin
CNQ40_RS16525 139242..139412 - 171 WP_002414857.1 hypothetical protein -
CNQ40_RS00655 139579..139827 + 249 WP_002414858.1 hypothetical protein -
CNQ40_RS00660 139915..140241 + 327 WP_002365226.1 hypothetical protein -
CNQ40_RS00665 140241..140645 + 405 WP_002414859.1 DUF961 family protein -
CNQ40_RS00670 140799..141035 + 237 WP_010775495.1 hypothetical protein -
CNQ40_RS00675 141038..141442 + 405 WP_002414860.1 hypothetical protein -
CNQ40_RS00680 141554..141886 + 333 WP_002414861.1 nucleotidyltransferase domain-containing protein -
CNQ40_RS00685 141876..142259 + 384 WP_002359294.1 DUF86 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - EF0149 130285..189079 58794


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(86-176)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-61)


Sequences

Toxin        


Download         Length: 213 a.a.        Molecular weight: 25219.19 Da        Isoelectric Point: 9.1721

>T106015 WP_002414854.1 NZ_CP029612:c138047-137409 [Enterococcus faecalis]
MILNKKKLYFETQAFTDKLINEISINMSKRKELINCYDIEAYVKETENIDFFDYPFKKQSKKLIWGSVTKIGDVTMVATA
QHLKIEIKNFTKMHEIIHHYFDYTTDIPNNEKSFDTLLIKKGYLPEDYPKEFRANKGAGMLLINKKALEYAFNTYTDFEK
MASFFNVNNIVLKIRILDELIYSHNLSYKQANLIYNGYYFQQQTQLKEILFK

Download         Length: 639 bp

>T106015 NZ_CP029612:c138047-137409 [Enterococcus faecalis]
ATGATACTTAATAAGAAAAAATTATATTTTGAAACACAGGCATTTACTGACAAACTTATAAATGAAATTTCAATCAATAT
GTCTAAAAGAAAAGAACTCATCAATTGTTATGATATTGAAGCCTACGTAAAAGAAACCGAAAATATTGATTTTTTTGATT
ATCCATTCAAAAAACAATCTAAAAAATTAATCTGGGGATCAGTAACAAAAATTGGTGATGTAACTATGGTAGCGACTGCC
CAACACTTGAAAATAGAAATTAAAAATTTTACGAAAATGCACGAAATAATTCATCATTATTTTGACTATACGACAGATAT
ACCTAACAATGAAAAATCATTTGATACACTACTTATAAAAAAGGGCTATCTCCCTGAAGATTATCCTAAAGAGTTCAGAG
CAAATAAGGGTGCCGGAATGTTACTTATTAATAAAAAAGCCTTAGAATATGCTTTTAACACTTATACTGATTTTGAAAAA
ATGGCTAGTTTTTTCAACGTAAACAATATAGTTCTCAAAATAAGGATTCTTGATGAATTAATTTACTCCCATAACTTATC
TTATAAACAAGCTAATCTTATTTACAATGGTTACTATTTTCAACAACAAACACAACTTAAAGAGATTTTATTCAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14439.25 Da        Isoelectric Point: 5.0808

>AT106015 WP_002414856.1 NZ_CP029612:c138428-138054 [Enterococcus faecalis]
METYEKIKSLRENKNITQQEVADAINMNISVYKKVELGSRPIRENELAKIADFFNVSSDYLLGRTKNPTSPQEDTTKVGE
NIISHFRLNTNDLSSDDIEELEKELIDFQEFLIKRAKERKKKSE

Download         Length: 375 bp

>AT106015 NZ_CP029612:c138428-138054 [Enterococcus faecalis]
ATGGAAACTTATGAAAAAATTAAATCACTAAGAGAAAACAAAAATATTACTCAACAAGAAGTAGCCGATGCTATCAATAT
GAATATAAGTGTCTATAAAAAAGTTGAATTAGGTTCTCGACCTATAAGAGAAAATGAACTAGCAAAAATTGCAGATTTTT
TCAATGTATCTTCTGACTATTTATTGGGAAGAACTAAAAATCCTACATCCCCCCAAGAAGATACAACTAAAGTAGGAGAA
AATATTATTTCTCATTTTAGATTAAACACTAATGATTTAAGCTCTGATGACATAGAAGAATTAGAAAAAGAATTGATTGA
TTTTCAAGAATTTCTTATAAAACGAGCAAAAGAAAGAAAAAAAAAGAGTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References