Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 81433..82084 | Replicon | plasmid unnamed |
Accession | NZ_CP029611 | ||
Organism | Acinetobacter pittii strain ST220 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A7H2WXC0 |
Locus tag | DLK06_RS21175 | Protein ID | WP_006581604.1 |
Coordinates | 81433..81789 (+) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | DLK06_RS21180 | Protein ID | WP_001140619.1 |
Coordinates | 81782..82084 (+) | Length | 101 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DLK06_RS21140 | 76529..76891 | + | 363 | Protein_100 | plasmid replication DNA-binding protein | - |
DLK06_RS21145 | 77091..77570 | - | 480 | Protein_101 | GIY-YIG nuclease family protein | - |
DLK06_RS21150 | 77624..78556 | + | 933 | WP_002048759.1 | IS5 family transposase | - |
DLK06_RS21155 | 78610..78960 | - | 351 | Protein_103 | GIY-YIG nuclease family protein | - |
DLK06_RS21160 | 79152..79454 | + | 303 | WP_000286963.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
DLK06_RS21165 | 79455..79736 | + | 282 | WP_000985610.1 | putative addiction module antidote protein | - |
DLK06_RS21170 | 79940..80812 | + | 873 | WP_006581603.1 | restriction endonuclease | - |
DLK06_RS21175 | 81433..81789 | + | 357 | WP_006581604.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
DLK06_RS21180 | 81782..82084 | + | 303 | WP_001140619.1 | XRE family transcriptional regulator | Antitoxin |
DLK06_RS21185 | 82077..82286 | + | 210 | WP_000069471.1 | hypothetical protein | - |
DLK06_RS21190 | 82396..82614 | - | 219 | WP_029747731.1 | hypothetical protein | - |
DLK06_RS21200 | 83371..83916 | - | 546 | Protein_111 | IS5 family transposase | - |
DLK06_RS21205 | 83844..84232 | - | 389 | Protein_112 | AAA family ATPase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | sul2 | - | 1..84302 | 84302 | |
- | flank | IS/Tn | - | - | 83584..83796 | 212 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13462.38 Da Isoelectric Point: 7.1642
>T106014 WP_006581604.1 NZ_CP029611:81433-81789 [Acinetobacter pittii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKDLRVQHRGKSLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKDLRVQHRGKSLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG
Download Length: 357 bp
>T106014 NZ_CP029611:81433-81789 [Acinetobacter pittii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11206.01 Da Isoelectric Point: 6.7282
>AT106014 WP_001140619.1 NZ_CP029611:81782-82084 [Acinetobacter pittii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV
Download Length: 303 bp
>AT106014 NZ_CP029611:81782-82084 [Acinetobacter pittii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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