Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 81433..82084 Replicon plasmid unnamed
Accession NZ_CP029611
Organism Acinetobacter pittii strain ST220

Toxin (Protein)


Gene name higB Uniprot ID A0A7H2WXC0
Locus tag DLK06_RS21175 Protein ID WP_006581604.1
Coordinates 81433..81789 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DLK06_RS21180 Protein ID WP_001140619.1
Coordinates 81782..82084 (+) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLK06_RS21140 76529..76891 + 363 Protein_100 plasmid replication DNA-binding protein -
DLK06_RS21145 77091..77570 - 480 Protein_101 GIY-YIG nuclease family protein -
DLK06_RS21150 77624..78556 + 933 WP_002048759.1 IS5 family transposase -
DLK06_RS21155 78610..78960 - 351 Protein_103 GIY-YIG nuclease family protein -
DLK06_RS21160 79152..79454 + 303 WP_000286963.1 type II toxin-antitoxin system RelE/ParE family toxin -
DLK06_RS21165 79455..79736 + 282 WP_000985610.1 putative addiction module antidote protein -
DLK06_RS21170 79940..80812 + 873 WP_006581603.1 restriction endonuclease -
DLK06_RS21175 81433..81789 + 357 WP_006581604.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DLK06_RS21180 81782..82084 + 303 WP_001140619.1 XRE family transcriptional regulator Antitoxin
DLK06_RS21185 82077..82286 + 210 WP_000069471.1 hypothetical protein -
DLK06_RS21190 82396..82614 - 219 WP_029747731.1 hypothetical protein -
DLK06_RS21200 83371..83916 - 546 Protein_111 IS5 family transposase -
DLK06_RS21205 83844..84232 - 389 Protein_112 AAA family ATPase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 - 1..84302 84302
- flank IS/Tn - - 83584..83796 212


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-106)

Antitoxin

(13-89)


Sequences


Toxin        


Download         Length: 119 a.a.        Molecular weight: 13462.38 Da        Isoelectric Point: 7.1642

>T106014 WP_006581604.1 NZ_CP029611:81433-81789 [Acinetobacter pittii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKDLRVQHRGKSLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Download         Length: 357 bp

>T106014 NZ_CP029611:81433-81789 [Acinetobacter pittii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11206.01 Da        Isoelectric Point: 6.7282

>AT106014 WP_001140619.1 NZ_CP029611:81782-82084 [Acinetobacter pittii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT106014 NZ_CP029611:81782-82084 [Acinetobacter pittii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7H2WXC0


Antitoxin

Source ID Structure

References